2. Gene
  3. Apoc3 - apolipoprotein C-III Gene

Apoc3 - apolipoprotein C-III Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as apo-CIII; apoC-III

Gene ID: 11814 | Gene type: protein coding

About Apoc3

Summary

This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total Cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Apoc3 Products(4)

mRNA Protein Name
NM_001289755.1 NP_001276684.1 apolipoprotein C-III isoform a
NM_001289756.1 NP_001276685.1 apolipoprotein C-III isoform b precursor
NM_001289833.1 NP_001276762.1 apolipoprotein C-III isoform c
NM_023114.4 NP_075603.1 apolipoprotein C-III isoform b precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
8089130 MGI
acts upstream of or within triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
11590213 MGI
acts upstream of or within triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
8089130 MGI
acts upstream of or within triglyceride mobilization IMP
IMP: Inferred from mutant phenotype
8864964 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apolipoprotein C-III

apolipoprotein C3

Recombinant Apoc3 Proteins

Cat. No. Product Name Accession Purity
HY-P72082 Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO) P33622 (E21-S99) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145727 Volanesorsen Inhibitor / Unkown
HY-145727A Volanesorsen sodium Inhibitor 94.25% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-153491 Olezarsen Inhibitor / Phase 3
HY-153491A Olezarsen sodium Inhibitor / Phase 3
HY-164740 Plozasiran Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00846 APOC3 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-164740A Plozasiran sodium Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apoc3 NCBI NCBI:345