Bad - BCL2-associated agonist of cell death Gene

Mus musculus

Also known as Bbc2

Gene ID: 12015 | Gene type: protein coding

About Bad

Summary

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of Glucokinase activity; and positive regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including apoptotic signaling pathway; modulation by virus of host apoptotic process; and positive regulation of lymphocyte differentiation. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic Cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]

Bad Products(2)

mRNA	Protein	Name
NM_001285453.1	NP_001272382.1	bcl2-associated agonist of cell death isoform 2
NM_007522.3	NP_031548.1	bcl2-associated agonist of cell death isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19915011	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7834748	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	12944463	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ADP metabolic process	IMP IMP: Inferred from mutant phenotype	18223655	MGI
involved in ATP metabolic process	IMP IMP: Inferred from mutant phenotype	18223655	MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19915011	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11717309	MGI
acts upstream of or within apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	12931191	MGI
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	18223655	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of or within epithelial cell proliferation	IDA IDA: Inferred from direct assay	9176392	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	12115603	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	12431371	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	14967141	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	12431371	MGI
acts upstream of or within glucose catabolic process	IMP IMP: Inferred from mutant phenotype	12931191	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12931191	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18223655	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12431371	MGI
acts upstream of or within positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	12431371	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	12431371	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21095239	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18223655	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	18223655	MGI
involved in positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IDA IDA: Inferred from direct assay	21716255	MGI
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	18223655	MGI
involved in positive regulation of type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	18223655	MGI
acts upstream of or within regulation of apoptotic process	IDA IDA: Inferred from direct assay	7834748	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14967141	MGI
acts upstream of or within release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	12431371	MGI
acts upstream of or within symbiont-mediated activation of host apoptosis	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis	IMP IMP: Inferred from mutant phenotype	15231831	MGI
involved in type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	18223655	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11146504	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11980919	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12931191	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bcl2-associated agonist of cell death

bcl-2-binding component 6	bcl-xL/Bcl-2-associated death promoter
bcl2 antagonist of cell death

Bad Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bad	Q61337	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	15694340
Cross	Bad	Q61337	YWHAZ	Homo sapiens	P63104	Pull Down	11723239
Intra	Bad	Q61337	Bcl2l1	Mus musculus	Q64373-1	Anti Bait CoIP	23332762
Cross	Bad	Q61337	BCL2	Homo sapiens	P10415	Anti Tag CoIP	15694340
Cross	Bad	Q61337	BCL2	Homo sapiens	P10415	FPS	16697956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14266	Dapivirine		99.80%	Phase 3
HY-119368	NPB	Inhibitor	≥98.0%	Phase 3
HY-50868	Bafetinib		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18095	CX-6258	Inhibitor	98.71%	Unkown
HY-18095A	CX-6258 hydrochloride hydrate	Inhibitor	99.23%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.83%	Unkown
HY-18095B	CX-6258 hydrochloride	Inhibitor	99.03%	Unkown
HY-P2468	BAD (103-127) (human)	Inhibitor	98.80%	Unkown
HY-14266S	Dapivirine-d11		/	Unkown
HY-P2499	BAD (103-127) (human), FAM-labeled	Inhibitor	/	Unkown
HY-120035	DD1		99.40%	Unkown
HY-14266A	Dapivirine hydrochloride		/	Unkown
HY-14266S1	Dapivirine-d4		/	Unkown
HY-145844	EGFR-IN-44		/	Unkown
HY-146395	HBV-IN-23		/	Unkown
HY-147342	β-Benzamide adenine dinucleotide	Inhibitor	/	Unkown
HY-15901	LGB321	Inhibitor	/	Unkown
HY-15901A	LGB321 monohydrochloride	Inhibitor	/	Unkown
HY-168338	CB2 receptor agonist 8		/	Unkown
HY-P5324	Bad BH3 (mouse)		/	Unkown
HY-RS01341	BAD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bad	NCBI	NCBI:572
Macaca fascicularis	Bad	NCBI	NCBI:102121921

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