BAD - BCL2 associated agonist of cell death Gene

Homo sapiens

Also known as BBC2; BCL2L8

Gene ID: 572 | Gene type: protein coding

About BAD

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,269,828-64,284,704 (from NCBI)

This gene has 7 transcripts (splice variants) and 79 orthologues. Ubiquitous expression in colon (RPKM 20.0), fat (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Bcl-2 Family. Bcl-2 Family members are known to be regulators of programmed cell death. This protein positively regulates cell Apoptosis by forming heterodimers with Bcl-xL (B-cell lymphoma-extra large) and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases Akt and MAP kinase, as well as protein phosphatase Calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

BAD Products(2)

mRNA	Protein	Name
NM_004322.3	NP_004313.1	bcl2-associated agonist of cell death
NM_032989.3	NP_116784.1	bcl2-associated agonist of cell death

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	19667065	GOA
enables phospholipid binding	IMP IMP: Inferred from mutant phenotype	21081150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9388232	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17270021	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	19667065	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in cellular response to nicotine	IDA IDA: Inferred from direct assay	18676776	GOA
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	18852119	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	18676776	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in pore complex assembly	IDA IDA: Inferred from direct assay	19667065	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9388232	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19593445	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	20700721	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BAD-BCL-2 complex	IPI IPI: Inferred from physical interaction	9463381	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20700721	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	20700721	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAD Protein Structure

Bcl-2_BAD

0
100
168 a.a.

Protein Preferred Names

Protein Names

bcl2-associated agonist of cell death

BCL-X/BCL-2 binding protein

Related Diseases

Diseases

Alias

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14266	Dapivirine		99.80%	Phase 3
HY-119368	NPB	Inhibitor	≥98.0%	Phase 3
HY-50868	Bafetinib		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18095	CX-6258	Inhibitor	98.71%	Unkown
HY-18095A	CX-6258 hydrochloride hydrate	Inhibitor	99.23%	Unkown
HY-18095B	CX-6258 hydrochloride	Inhibitor	99.03%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.83%	Unkown
HY-P2468	BAD (103-127) (human)	Inhibitor	98.80%	Unkown
HY-14266S	Dapivirine-d11		/	Unkown
HY-P2499	BAD (103-127) (human), FAM-labeled	Inhibitor	/	Unkown
HY-120035	DD1		99.40%	Unkown
HY-14266A	Dapivirine hydrochloride		/	Unkown
HY-145844	EGFR-IN-44		/	Unkown
HY-146395	HBV-IN-23		/	Unkown
HY-147342	β-Benzamide adenine dinucleotide		/	Unkown
HY-15901	LGB321	Inhibitor	/	Unkown
HY-15901A	LGB321 monohydrochloride	Inhibitor	/	Unkown
HY-P5324	Bad BH3 (mouse)		/	Unkown
HY-RS01341	BAD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BAD	VGNC	VGNC:102738
Bos taurus	BAD	VGNC	VGNC:26404
Mus musculus	BAD	MGD	MGI:1096330
Canis familiaris	BAD	VGNC	VGNC:38362
Rattus norvegicus	BAD	RGD	RGD:620103
Macaca mulatta	BAD	VGNC	VGNC:70218
Macaca fascicularis	BAD	NCBI	NCBI:102121921
Others	BAD	NCBI

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