ASCL4 - achaete-scute family bHLH transcription factor 4 Gene

Homo sapiens

Also known as ASH-4; HASH4; bHLHa44

Gene ID: 121549 | Gene type: protein coding

About ASCL4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,774,704-107,776,644 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 4 paralogues.

Summary

Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]

ASCL4 Products(1)

mRNA	Protein	Name
NM_203436.3	NP_982260.3	achaete-scute homolog 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASCL4 Protein Structure

HLH

0
100
173 a.a.

Protein Preferred Names

Protein Names

achaete-scute homolog 4

achaete-scute complex homolog 4

ASCL4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASCL4	Q6XD76	DNAJB6	Homo sapiens	O75190	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	DNAJB6	Homo sapiens	O75190	Y2H Array	32814053
Intra	ASCL4	Q6XD76	DNAJB6	Homo sapiens	O75190	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	ASCL4	Q6XD76	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ASCL4	Q6XD76	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ASCL4	Q6XD76	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	ASCL4	Q6XD76	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	ASCL4	Q6XD76	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	ASCL4	Q6XD76	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ASCL4	Q6XD76	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ASCL4	Q6XD76	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ASCL4	Q6XD76	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ASCL4	Q6XD76	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ASCL4	Q6XD76	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ASCL4	Q6XD76	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	ASCL4	Q6XD76	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	ACTA1	Homo sapiens	P68133	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	ACTA1	Homo sapiens	P68133	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	ACTA1	Homo sapiens	P68133	Y2H Array	32814053
Intra	ASCL4	Q6XD76	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	ASCL4	Q6XD76	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	GRB2	Homo sapiens	P62993	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	GRB2	Homo sapiens	P62993	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	GRB2	Homo sapiens	P62993	Y2H Array	32814053
Intra	ASCL4	Q6XD76	CYCS	Homo sapiens	P99999	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	CYCS	Homo sapiens	P99999	Y2H Array	32814053
Intra	ASCL4	Q6XD76	CYCS	Homo sapiens	P99999	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ASCL4	Q6XD76	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	ASCL4	Q6XD76	SRC	Homo sapiens	P12931	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	SRC	Homo sapiens	P12931	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	SRC	Homo sapiens	P12931	Y2H Array	32814053
Intra	ASCL4	Q6XD76	ID2	Homo sapiens	Q02363	Anti Tag CoIP	33961781
Intra	ASCL4	Q6XD76	ID2	Homo sapiens	Q02363	Y2H Prey Pooling	32296183
Intra	ASCL4	Q6XD76	ID2	Homo sapiens	Q02363	Y2H Array	32296183
Intra	ASCL4	Q6XD76	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	ASCL4	Q6XD76	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ASCL4	Q6XD76	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	ASCL4	Q6XD76	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	33961781
Intra	ASCL4	Q6XD76	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	ASCL4	Q6XD76	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	ASCL4	Q6XD76	RAB11A	Homo sapiens	P62491	Y2H Array	32814053
Intra	ASCL4	Q6XD76	RAB11A	Homo sapiens	P62491	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	RAB11A	Homo sapiens	P62491	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ASCL4	Q6XD76	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	ASCL4	Q6XD76	ESR1	Homo sapiens	P03372	Y2H Array	32814053
Intra	ASCL4	Q6XD76	ESR1	Homo sapiens	P03372	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	ESR1	Homo sapiens	P03372	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	ATP1A3	Homo sapiens	P13637	Validated Y2H	32814053
Intra	ASCL4	Q6XD76	ATP1A3	Homo sapiens	P13637	Y2H Pooling	32814053
Intra	ASCL4	Q6XD76	ATP1A3	Homo sapiens	P13637	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 33

DEE33	Epileptic Encephalopathy, Early Infantile, 33
Eiee33	Developmental And Epileptic Encephalopathy, 33
Early Infantile Epileptic Encephalopathy 33	Encephalopathy, Epileptic, Early Infantile, Type 33

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01081	ASCL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASCL4	VGNC	VGNC:38176
Mus musculus	ASCL4	MGD	MGI:1914591
Macaca mulatta	ASCL4	VGNC	VGNC:108324
Bos taurus	ASCL4	VGNC	VGNC:26208
Rattus norvegicus	ASCL4	RGD	RGD:1307533

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