2. Gene
  3. Cck - cholecystokinin Gene

Cck - cholecystokinin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 12424 | Gene type: protein coding

About Cck

Summary

This gene encodes a member of the Gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide Hormones cholecystokinin-8, -12, -33, and Others. The encoded Peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired Insulin secretion, enhanced Insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Cck Products(3)

mRNA Protein Name
NM_001284508.3 NP_001271437.1 cholecystokinin isoform 2 precursor
NM_001410236.1 NP_001397165.1 cholecystokinin isoform 1 preproprotein
NM_031161.5 NP_112438.1 cholecystokinin isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
15374756 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8876222 MGI
enables receptor ligand activity IPI
IPI: Inferred from physical interaction
8876222 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
15152034 MGI
involved in cholecystokinin signaling pathway IPI
IPI: Inferred from physical interaction
8876222 MGI
acts upstream of or within eating behavior IDA
IDA: Inferred from direct assay
15374756 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
15152034 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
15152034 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cholecystokinin

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0093 Sincalide 99.51% Unkown
HY-103354 Proglumide sodium Antagonist 99.85% Yes
HY-B1330 Proglumide Antagonist 99.84% Yes
HY-P0093A Sincalide ammonium 99.90% Unkown
HY-103354A Proglumide hemicalcium Antagonist / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19445 Gastrazole Antagonist / Phase 3
HY-106840 L-365260 Antagonist 99.93% Phase 2
HY-14850 Sograzepide Antagonist 98.35% Phase 2
HY-101764 Lintitript Antagonist 99.58% Phase 2
HY-17617 Nastorazepide Antagonist 99.95% Phase 2
HY-106356 GV-150013 Antagonist / Phase 2
HY-19261 T-0632 Antagonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (72)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1097 Gastrin I, human 99.93% Unkown
HY-P2671 [Leu15]-Gastrin I (human) 99.93% Unkown
HY-106301 Devazepide Antagonist 99.58% Unkown
HY-P0196 Cholecystokinin Octapeptide, desulfated 99.54% Unkown
HY-P2932 Cholecystokinin 99.85% Unkown
HY-125556 Tetragastrin Agonist 99.60% Unkown
HY-103355 YM022 Antagonist 99.93% Unkown
HY-B1439B Lorglumide sodium salt Antagonist 99.19% Unkown
HY-107759 Butabindide oxalate Inhibitor 98.98% Unkown
HY-B2154 Loxiglumide Antagonist ≥98.0% Unkown
HY-P1096 A71623 Agonist 99.90% Unkown
HY-106840A L-365260 hemihydrate Antagonist 99.75% Unkown
HY-124187 Pinolenic acid ethyl ester ≥98.0% Unkown
HY-P0196A Cholecystokinin Octapeptide, desulfated TFA 97.17% Unkown
HY-P2636 Cholecystokinin Precursor (24-32) (rat) 99.54% Unkown
HY-148656 PNB-001 Antagonist 99.65% Unkown
HY-U00360 (Rac)-Sograzepide Antagonist 98.98% Unkown
HY-105226B CI-988 hemihydrate Antagonist / Unkown
HY-118194 A-65186 Antagonist 99.94% Unkown
HY-129357 CCK-B Receptor Antagonist 2 Inhibitor 98.84% Unkown
HY-P2932A Cholecystokinin-33 free acid 95.05% Unkown
HY-101352 LY 225910 Antagonist 98.92% Unkown
HY-U00062 Tarazepide Antagonist / Unkown
HY-100481 RP 72540 Antagonist / Unkown
HY-103357 LY288513 Antagonist / Unkown
HY-103357A LY262691 Antagonist / Unkown
HY-105226 CI-988 Antagonist / Unkown
HY-105955 FPL 14294 / Unkown
HY-111313 JNJ-26070109 Antagonist / Unkown
HY-111918 A71378 Agonist / Unkown
HY-113896 U-67827E Agonist / Unkown
HY-117839 PD-135666 Inhibitor / Unkown
HY-118314 CI-1015 / Unkown
HY-118546 JNJ-17156516 Antagonist / Unkown
HY-120381 PD 136450 Antagonist / Unkown
HY-121278 Benzotript Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown
HY-128941 CCK2R Ligand-Linker Conjugates 1 / Unkown
HY-150070 Butabindide Inhibitor / Unkown
HY-155205 GV150013X Antagonist / Unkown
HY-172281 DSPE-PEG1000-CCK8 / Unkown
HY-172281A DSPE-PEG2000-CCK8 / Unkown
HY-172281B DSPE-PEG5000-CCK8 / Unkown
HY-P1133 Galanin (2-29) (rat) Agonist / Unkown
HY-P1710 ARL 15849XX Agonist / Unkown
HY-P1800 Caerulein, desulfated Control / Unkown
HY-P1988 JMV 179 Antagonist / Unkown
HY-P2121 JMV 176 Agonist / Unkown
HY-P2165 N-acetyl CCK-(26-30) amide Antagonist / Unkown
HY-P2424 Cholecystokinin-J / Unkown
HY-P2592 Ro 23-7014 / Unkown
HY-P2627 CCK (27-33) / Unkown
HY-P2677 CCK (26-31) sulfated / Unkown
HY-P2678 CCK (26-31) non-sulfated Agonist / Unkown
HY-P3650 Cholecystokinin (1-21) / Unkown
HY-P3652 Cholecystokinin-33 (swine) Agonist / Unkown
HY-P3704 Enterostatin (rat) / Unkown
HY-P5526 CCK1-specific peptide substrate / Unkown
HY-RS02073 CCK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00363 CHEMBL333994 Antagonist / Unkown
HY-116576 LY219057 Antagonist / Unkown
HY-118665 L-736380 Antagonist / Unkown
HY-118904 VL-0395 Antagonist / Unkown
HY-125314 AG-041R Antagonist / Unkown
HY-125610 DA-3934 Antagonist / Unkown
HY-129516 A-70874 Agonist / Unkown
HY-129759 KSG-504 anhydrous Inhibitor / Unkown
HY-14575 Nastorazepide hemicalcium Antagonist / Unkown
HY-162070 CCK antagonist 1 Antagonist 99.96% Unkown
HY-P2638 Cholecystokinin (27-32)-amide Antagonist / Unkown
HY-U00375 Gastrin/CCK antagonist 1 Antagonist / Unkown
HY-U00387 CCK-A receptor inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cck NCBI NCBI:885
Macaca fascicularis Cck NCBI NCBI:101926217
Leporidae Cck NCBI
Rattus norvegicus Cck NCBI NCBI:25298
Macaca mulatta Cck NCBI NCBI:100430777