1. Gene
  2. Cck - cholecystokinin Gene

Cck - cholecystokinin Gene

Mus musculus
Gene ID: 12424 | Gene type: protein coding

About Cck

Summary

This gene encodes a member of the Gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide Hormones cholecystokinin-8, -12, -33, and Others. The encoded Peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired Insulin secretion, enhanced Insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Cck Products(3)

mRNA Protein Name
NM_001284508.3 NP_001271437.1 cholecystokinin isoform 2 precursor
NM_001410236.1 NP_001397165.1 cholecystokinin isoform 1 preproprotein
NM_031161.5 NP_112438.1 cholecystokinin isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
15374756 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8876222 MGI
enables receptor ligand activity IPI
IPI: Inferred from physical interaction
8876222 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
15152034 MGI
involved in cholecystokinin signaling pathway IPI
IPI: Inferred from physical interaction
8876222 MGI
acts upstream of or within eating behavior IDA
IDA: Inferred from direct assay
15374756 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
15152034 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
15152034 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cholecystokinin

Orthologs Information

Species Symbol Source ID
Homo sapiens Cck NCBI NCBI:885
Macaca fascicularis Cck NCBI NCBI:101926217
Leporidae Cck NCBI
Rattus norvegicus Cck NCBI NCBI:25298
Macaca mulatta Cck NCBI NCBI:100430777