2. Gene
  3. Cd38 - CD38 antigen Gene

Cd38 - CD38 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as I-19; ADPRC 1; Cd38-rs1

Gene ID: 12494 | Gene type: protein coding

About Cd38

Chromosome 5: 44,025,895-44,069,717 forward strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 23 phenotypes. Broad expression in large intestine adult (RPKM 24.5), colon adult (RPKM 16.5) and 21 other tissues.

Summary

This gene encodes a non-lineage-restricted, type II Transmembrane Glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]

Cd38 Products(1)

mRNA Protein Name
NM_007646.6 NP_031672.2 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables hydrolase activity, acting on glycosyl bonds IMP
IMP: Inferred from mutant phenotype
12403647 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22863568 MGI
enables phosphorus-oxygen lyase activity IMP
IMP: Inferred from mutant phenotype
12403647 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
9324354 MGI
located in membrane IDA
IDA: Inferred from direct assay
12403647 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd38 Protein Structure

Rib_hydrolayse

Rib_hydrolayse: pfam02267 (58 - 287)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

2'-phospho-ADP-ribosyl cyclase

2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

2'-phospho-cyclic-ADP-ribose transferase

ADP-ribosyl cyclase 1

NIM-R5 antigen

cADPr hydrolase 1

cyclic ADP-ribose hydrolase 1

Recombinant Cd38 Proteins

Cat. No. Product Name Accession Purity
HY-P70044 CD38 Protein, Mouse (HEK293, Fc) P56528 (L45-T304) ≥95%
HY-P72732 CD38 Protein, Mouse (HEK293, His) P56528 (L45-T304) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9915 Daratumumab 99.00% Unkown
Clinical Phase
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P9915A Daratumumab (PBS) ≥95.0% Phase 4
HY-P99730 Mezagitamab Inhibitor 99.76% Phase 3
HY-P9976A Isatuximab (anti-CD38) 98.44% Phase 3
HY-P99616 Felzartamab Inhibitor 99.34% Phase 2
HY-P99744 Modakafusp alfa Inhibitor 96.22% Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123999 CD38 inhibitor 1 99.83% Unkown
HY-N0640 Kuromanin chloride Inhibitor 99.50% Unkown
HY-150508 MK-0159 Inhibitor 99.72% Unkown
HY-144987 RBN013209 98.87% Unkown
HY-129997 Luteolinidin chloride Inhibitor 99.14% Unkown
HY-156120 CD38 inhibitor 3 Inhibitor 98.39% Unkown
HY-144988 CD38 inhibitor 2 98.81% Unkown
HY-134358A Ara-F-NAD+ sodium Inhibitor 99.81% Unkown
HY-134358 Ara-F-NAD+ Inhibitor / Unkown
HY-P10563 Noraramtide / Unkown
HY-119648A (E/Z)-CCR-11 Inhibitor 98.00% Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990273 Anti-Mouse CD38 Antibody (NIMR5) Inhibitor 95.00% Unkown
HY-P990037 Erzotabart Inhibitor 99.00% Unkown
HY-P990747 Lumrotatug Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd38 NCBI NCBI:952
Macaca fascicularis Cd38 NCBI NCBI:102126394
Leporidae Cd38 NCBI
Rattus norvegicus Cd38 NCBI NCBI:25668