Cd38 - CD38 molecule Gene

Rattus norvegicus

Also known as ADPRC 1

Gene ID: 25668 | Gene type: protein coding

About Cd38

Primary_assembly 14: 67,172,063-67,211,986 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 249.7), Lung (RPKM 118.2) and 8 other tissues.

Summary

Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd38 Products(1)

mRNA	Protein	Name
NM_013127.2	NP_037259.1	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: Inferred from direct assay	11733184	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in artery smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	21431168	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	14998907	RGD
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	10097163	RGD
involved in negative regulation of bone resorption	IDA IDA: Inferred from direct assay	10477767	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	19696022	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18719074	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19696022	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	18719074	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	9664081	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	18524860	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	11399650	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14998907	RGD
involved in response to hormone	IDA IDA: Inferred from direct assay	9325179	RGD
involved in response to hydroperoxide	IDA IDA: Inferred from direct assay	12893282	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12111041	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	11399650	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	14998907	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	11399650	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	21784055	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	11733184	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd38 Protein Structure

Rib_hydrolayse

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

2'-phospho-ADP-ribosyl cyclase	2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
2'-phospho-cyclic-ADP-ribose transferase	ADP-ribosyl cyclase 1
CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)	CD38H
cADPr hydrolase 1	cyclic ADP-ribose hydrolase 1

Recombinant Cd38 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70077	CD38 Protein, Rat (HEK293, His)	Q64244 (W45-V303)	≥95%
HY-P72897	CD38 Protein, Rat (HEK293, Fc)	Q64244 (W45-V303)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9915	Daratumumab		99.00%	Unkown

Clinical Phase

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9915A	Daratumumab (PBS)		≥95.0%	Phase 4
HY-P99730	Mezagitamab	Inhibitor	99.76%	Phase 3
HY-P99616	Felzartamab	Inhibitor	99.34%	Phase 3
HY-P9976A	Isatuximab (anti-CD38)		98.44%	Phase 3
HY-P99744	Modakafusp alfa	Inhibitor	96.22%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123999	CD38 inhibitor 1		99.83%	Unkown
HY-N0640	Kuromanin chloride	Inhibitor	99.50%	Unkown
HY-150508	MK-0159	Inhibitor	99.72%	Unkown
HY-144987	RBN013209		98.84%	Unkown
HY-129997	Luteolinidin chloride	Inhibitor	99.14%	Unkown
HY-156120	CD38 inhibitor 3	Inhibitor	99.16%	Unkown
HY-144988	CD38 inhibitor 2		98.81%	Unkown
HY-134358A	Ara-F-NAD+ sodium	Inhibitor	99.81%	Unkown
HY-134358	Ara-F-NAD+	Inhibitor	/	Unkown
HY-171417	6-Alkyne-F-araNAD	Inhibitor	/	Unkown
HY-P10563	Noraramtide		/	Unkown
HY-119648A	(E/Z)-CCR-11	Inhibitor	98.00%	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990273	Anti-Mouse CD38 Antibody (NIMR5)	Inhibitor	95.00%	Unkown
HY-P990037	Erzotabart	Inhibitor	99.00%	Unkown
HY-P990747	Lumrotatug	Inhibitor	97.00%	Unkown
HY-P991183	SAR-442257	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd38	NCBI	NCBI:952
Macaca fascicularis	Cd38	NCBI	NCBI:102126394
Mus musculus	Cd38	NCBI	NCBI:12494
Leporidae	Cd38	NCBI

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