Ccr5 - chemokine (C-C motif) receptor 5 Gene

Mus musculus

Also known as AM4-7; CD195; Cmkbr5

Gene ID: 12774 | Gene type: protein coding

About Ccr5

Chromosome 9: 123,921,580-123,947,736 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 151 orthologues, 25 paralogues and is associated with 50 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.2), mammary gland adult (RPKM 2.1) and 27 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif Chemokine Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccr5 Products(1)

mRNA	Protein	Name
NM_009917.5	NP_034047.2	C-C chemokine receptor type 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-C chemokine binding	IPI IPI: Inferred from physical interaction	9139699	MGI
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	8631787	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	10528159	MGI
involved in negative regulation of macrophage apoptotic process	IDA IDA: Inferred from direct assay	16208318	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	23620790	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16301745	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr5 Protein Structure

7tmA_CCR5_CCR2

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 5

C-C CKR-5	CC-CKR-5
CCR-5	MIP-1 alpha receptor
chemokine (C-C) receptor 5

Recombinant Ccr5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700540	CCR5 Protein, Mouse (P. pastoris, His)	P51682 (Q263-L354)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13004	Maraviroc	Antagonist	99.88%	Yes
HY-117621	PF-04634817	Antagonist	98.87%	Unkown
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.01%	Phase 3
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.04%	Phase 3
HY-17377	Vicriviroc maleate	Antagonist	99.91%	Phase 3
HY-17450A	Aplaviroc hydrochloride	Antagonist	99.93%	Phase 3
HY-17450	Aplaviroc	Antagonist	/	Phase 3
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-P1034	DAPTA	Inhibitor	99.85%	Phase 2
HY-14230	INCB9471	Antagonist	/	Phase 2
HY-19974	TAK-220	Antagonist	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13406	TAK-779	Antagonist	99.73%	Unkown
HY-101713	Ilacirnon	Inhibitor	99.87%	Unkown
HY-119101	AZD-5672	Antagonist	95.74%	Unkown
HY-111069	Nifeviroc	Inhibitor	98.17%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-111321	Fuscin	Inhibitor	/	Unkown
HY-108432	BMS-741672	Antagonist	/	Unkown
HY-103406	PNU-177864	Inhibitor	/	Unkown
HY-162512	CB-0821	Inhibitor	/	Unkown
HY-152132	CCR5 antagonist 3	Inhibitor	/	Unkown
HY-100261	CCR5 antagonist 1	Antagonist	/	Unkown
HY-152131	CCR5 antagonist 2	Antagonist	/	Unkown
HY-123902	Ophiobolin C	Inhibitor	/	Unkown
HY-P4191A	Met-RANTES (human) (acetate)	Antagonist	99.62%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr5	NCBI	NCBI:1234

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