Epha2 - Eph receptor A2 Gene

Mus musculus

Also known as Eck; Myk2; Sek2; Sek-2

Gene ID: 13836 | Gene type: protein coding

About Epha2

Summary

Predicted to enable growth factor binding activity and transmembrane-ephrin receptor activity. Involved in several processes, including animal organ development; osteoblast differentiation; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EphA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Apr 2022]

Epha2 Products(1)

mRNA	Protein	Name
NM_010139.3	NP_034269.2	ephrin type-A receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16782872	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axial mesoderm formation	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	19443703	MGI
involved in bone remodeling	IMP IMP: Inferred from mutant phenotype	19299512	MGI
involved in branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	19321667	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	14988728	MGI
involved in ephrin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18948590	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	19443703	MGI
involved in lens fiber cell morphogenesis	IDA IDA: Inferred from direct assay	18948590	MGI
involved in mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19321667	MGI
acts upstream of or within negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within negative regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within negative regulation of lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	15145949	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15145949	MGI
acts upstream of or within notochord cell development	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within notochord formation	IGI IGI: Inferred from genetic interaction	11287184	MGI
acts upstream of or within notochord formation	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within notochord morphogenesis	IMP IMP: Inferred from mutant phenotype	11287184	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19299512	MGI
involved in osteoclast differentiation	IDA IDA: Inferred from direct assay	19299512	MGI
acts upstream of or within pericyte cell differentiation	IMP IMP: Inferred from mutant phenotype	19443703	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	11287184	MGI
involved in regulation of angiogenesis	IDA IDA: Inferred from direct assay	16782872	MGI
involved in regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	16782872	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	11287184	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	11287184	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	27733379	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-A receptor 2

epithelial cell kinase	tyrosine-protein kinase receptor ECK
tyrosine-protein kinase receptor MPK-5	tyrosine-protein kinase receptor SEK-2

Epha2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Epha2	Q03145	Epha4	Mus musculus	Q03137	Protein Kinase Assay	16977320

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Epha2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75240	EphA2 Protein, Mouse (HEK293, His)	Q03145 (K26-N535)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159174	EPHA2/A4/GAK-IN-1	Inhibitor	/	Unkown
HY-163835	UniPR1454	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epha2	NCBI	NCBI:1969
Macaca fascicularis	Epha2	NCBI	NCBI:102146108

Name
Email *

	Sorry, but the email address you supplied was invalid.