Erbb2 - erb-b2 receptor tyrosine kinase 2 Gene

Mus musculus

Also known as Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

Gene ID: 13866 | Gene type: protein coding

About Erbb2

Chromosome 11: 98,303,296-98,328,542 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 200 orthologues, 53 paralogues and is associated with 54 phenotypes. Broad expression in colon adult (RPKM 5.3), duodenum adult (RPKM 35.2) and 17 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; HSP90 protein binding activity; and Enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Erbb2 Products(1)

mRNA	Protein	Name
NM_001003817.1	NP_001003817.1	receptor tyrosine-protein kinase erbB-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IMP IMP: Inferred from mutant phenotype	22019888	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10878805	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8702723	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	12621152	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-EGFR signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in ERBB2-EGFR signaling pathway	IGI IGI: Inferred from genetic interaction	16357442	MGI
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in ERBB2-ERBB3 signaling pathway	IMP IMP: Inferred from mutant phenotype	10399934	MGI
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9556621	MGI
involved in ERBB2-ERBB4 signaling pathway	IGI IGI: Inferred from genetic interaction	12621152	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
acts upstream of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	16230479	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	10655525	MGI
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within negative regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	16230479	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	15496447	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	10655525	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	22184199	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	22184199	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19139271	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	22019888	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24364879	MGI
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22019888	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	22019888	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15306553	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15306553	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23553667	MGI
located in myelin sheath	IDA IDA: Inferred from direct assay	15044753	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	22184199	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	22184199	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	8702723	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23553667	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24803543	MGI
part of semaphorin receptor complex	IMP IMP: Inferred from mutant phenotype	22019888	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb2 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB2

PTKc_HER2

0
200
400
600
800
1000
1256 a.a.

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-2

Neu oncogene	avian erythroblastosis oncogene B 2
c-erbB-2	p185erbB2
proto-oncogene NEU	proto-oncogene c-ErbB-2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant Erbb2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73929	HER2/CD340 Protein, Mouse (HEK293, His)	P70424 (T23-T653)	≥95%
HY-P73930	HER2/CD340 Protein, Mouse (HEK293, Fc)	P70424 (T23-T653)	≥95%

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-50898	Lapatinib	99.83%	Yes
HY-13272	Dacomitinib	99.74%	Yes
HY-50898A	Lapatinib ditosylate	99.98%	Yes
HY-50898B	Lapatinib ditosylate monohydrate	99.93%	Yes
HY-50898C	Lapatinib tosylate	/	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13314	Tesevatinib	Inhibitor	99.21%	Phase 3
HY-16069A	Tucatinib hemiethanolate	Inhibitor	99.97%	Phase 3
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2
HY-10367	Canertinib	Inhibitor	99.82%	Phase 2
HY-32718	Pelitinib	Inhibitor	98.80%	Phase 2
HY-14674	CP-724714		98.53%	Phase 2
HY-10045	AEE788		99.13%	Phase 2
HY-10367A	Canertinib dihydrochloride	Inhibitor	99.68%	Phase 2
HY-10322	Falnidamol	Inhibitor	99.05%	Phase 1
HY-135366	HPN-01	Inhibitor	98.61%	Phase 1
HY-103443	HKI-357	Inhibitor	99.65%	Phase 1
HY-116437	Selatinib	Inhibitor	99.83%	Phase 1
HY-10346A	AV-412 free base	Inhibitor	98.33%	Phase 1
HY-10346	AV-412	Inhibitor	99.17%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13896	PD168393		98.58%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-15844	AG-825		98.02%	Unkown
HY-13427	Allitinib tosylate	Inhibitor	99.83%	Unkown
HY-20878	Tyrphostin AG 879		99.85%	Unkown
HY-W006886	Fmoc-(R)-2-(7-octenyl)Ala-OH		98.85%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	Unkown
HY-N1166	Tephrosin		98.02%	Unkown
HY-150023	BI-1622	Inhibitor	98.97%	Unkown
HY-101042	AG-494	Inhibitor	99.31%	Unkown
HY-112420	EGFR/ErbB-2/ErbB-4 inhibitor-2	Inhibitor	99.45%	Unkown
HY-100499	Tyrphostin AG 528	Inhibitor	≥98.0%	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	Unkown
HY-50898S	Lapatinib-d4		99.02%	Unkown
HY-103439	GW583340 dihydrochloride	Inhibitor	/	Unkown
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	Unkown
HY-15375	Allitinib	Inhibitor	99.36%	Unkown
HY-147407	Imbotolimod		/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-13272S3	Dacomitinib-d10		/	Unkown
HY-137028	2′-Thioadenosine	Inhibitor	/	Unkown
HY-156639	EGFR/ErbB-2 inhibitor-1	Inhibitor	/	Unkown
HY-160068	2-2(t) aptamer sodium	Chemical	/	Unkown
HY-168577	KRAS G12D inhibitor 25	Inhibitor	/	Unkown
HY-50898S1	Lapatinib-d7 dihydrochloride		/	Unkown
HY-50898S2	Lapatinib-d5		/	Unkown
HY-50898S3	Lapatinib-d4-1		/	Unkown
HY-P4082	ErbB-2-binding peptide		99.83%	Unkown
HY-RS04466	ERBB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04467	Erbb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04468	ERBB2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W008914	(E/Z)-CP-724714	Inhibitor	/	Unkown
HY-103443A	HKI-357 dimaleate	Inhibitor	/	Unkown
HY-129288	GW837016X	Inhibitor	/	Unkown
HY-164548	WK88-1		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990695	Lunaxafusp	Inhibitor	/	Unkown
HY-P990697	Anvatabart	Inhibitor	/	Unkown
HY-P99558	Timigutuzumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb2	NCBI	NCBI:2064
Canis familiaris	Erbb2	NCBI	NCBI:403883
Macaca fascicularis	Erbb2	NCBI	NCBI:102146608
Rattus norvegicus	Erbb2	NCBI	NCBI:24337
Macaca mulatta	Erbb2	NCBI	NCBI:697573

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