ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

Rattus norvegicus

Also known as neu; HER2/neu

Gene ID: 24337 | Gene type: protein coding

About ERBB2

Primary_assembly 10: 83,411,313-83,435,078 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 54 paralogues and is associated with 83 phenotypes. Biased expression in Kidney (RPKM 121.3), Lung (RPKM 59.5) and 8 other tissues.

Summary

Enables HSP90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

ERBB2 Products(1)

mRNA	Protein	Name
NM_017003.2	NP_058699.2	receptor tyrosine-protein kinase erbB-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	15671027	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9271418	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	1359541	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16168116	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15671027	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	19632177	RGD
involved in axon regeneration	IMP IMP: Inferred from mutant phenotype	23437108	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	30813222	RGD
involved in estrous cycle	IMP IMP: Inferred from mutant phenotype	11956173	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21186272	RGD
involved in glial cell differentiation	IGI IGI: Inferred from genetic interaction	12853432	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	12454858	RGD
involved in mammary gland involution	IEP IEP: Inferred from expression pattern	10653587	RGD
involved in multicellular organismal response to stress	IEP IEP: Inferred from expression pattern	27133902	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12673197	RGD
involved in peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	15496447	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16168116	RGD
involved in positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	12673197	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9271418	RGD
involved in positive regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	30813222	RGD
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	16859650	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16168116	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	1359541	RGD
involved in response to axon injury	IDA IDA: Inferred from direct assay	15800203	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	27133902	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	26892146	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	17459743	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	27209698	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18184445	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	8846777	RGD
involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	15496447	RGD
involved in tongue development	IEP IEP: Inferred from expression pattern	10908606	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15499570	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	15499570	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15499570	RGD
located in lateral loop	IDA IDA: Inferred from direct assay	15800203	RGD
located in microvillus	IDA IDA: Inferred from direct assay	15800203	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16859650	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15800203	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	7589796	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERBB2 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB2

PTKc_HER2

PHA03247

0
200
400
600
800
1000
1259 a.a.

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-2

Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)	C-erbB-2
NEU proto-oncogene	epidermal growth factor receptor-related protein
p185erbB2	p185neu
proto-oncogene NEU	proto-oncogene c-ErbB-2
receptor tyrosine-protein kinase erbB-2-like	v-erb-b2 avian erythroblastic leukemia viral oncogene 2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant ERBB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72626	HER2/CD340 Protein, Rat (His)	P06494 (A67-V323)	≥95%
HY-P73097	HER2/CD340 Protein, Rat (HEK293)	AAH61863 (T26-T656, with seven additional amino acids (ALEVLFQ) at the C-terminus)	≥95%
HY-P74895	HER2/CD340 Protein, Rat (HEK293, His)	AAH61863 (M4-T656)	≥95%
HY-P74896	HER2/CD340 Protein, Rat (HEK293, Fc)	AAH61863 (T26-T656)	≥95%

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50898	Lapatinib		99.83%	Yes
HY-13272	Dacomitinib		99.74%	Yes
HY-50898A	Lapatinib ditosylate		99.98%	Yes
HY-50898B	Lapatinib ditosylate monohydrate		99.93%	Yes
HY-16069A	Tucatinib hemiethanolate	Inhibitor	99.97%	Yes
HY-50898C	Lapatinib tosylate		/	Unkown

Clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2
HY-32718	Pelitinib	Inhibitor	98.80%	Phase 2
HY-10367	Canertinib	Inhibitor	99.82%	Phase 2
HY-14674	CP-724714		98.37%	Phase 2
HY-10045	AEE788		99.13%	Phase 2
HY-13427	Allitinib tosylate	Inhibitor	99.83%	Phase 2
HY-10367A	Canertinib dihydrochloride	Inhibitor	99.68%	Phase 2
HY-10322	Falnidamol	Inhibitor	99.41%	Phase 1
HY-103443	HKI-357	Inhibitor	99.65%	Phase 1
HY-135366	HPN-01	Inhibitor	98.61%	Phase 1
HY-10346A	AV-412 free base	Inhibitor	98.33%	Phase 1
HY-116437	Selatinib	Inhibitor	99.83%	Phase 1
HY-10346	AV-412	Inhibitor	99.17%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13896	PD168393		98.58%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-15844	AG-825		98.02%	Unkown
HY-20878	Tyrphostin AG 879		99.85%	Unkown
HY-W006886	Fmoc-(R)-2-(7-octenyl)Ala-OH		98.85%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	Unkown
HY-N1166	Tephrosin		98.02%	Unkown
HY-150023	BI-1622	Inhibitor	98.97%	Unkown
HY-101042	AG-494	Inhibitor	99.31%	Unkown
HY-112420	EGFR/ErbB-2/ErbB-4 inhibitor-2	Inhibitor	99.45%	Unkown
HY-100499	Tyrphostin AG 528	Inhibitor	≥98.0%	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	Unkown
HY-50898S	Lapatinib-d4		99.02%	Unkown
HY-15375	Allitinib	Inhibitor	99.36%	Unkown
HY-103439	GW583340 dihydrochloride	Inhibitor	/	Unkown
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	Unkown
HY-147407	Imbotolimod	Inhibitor	/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-13272S3	Dacomitinib-d10		/	Unkown
HY-137028	2′-Thioadenosine	Inhibitor	/	Unkown
HY-156639	EGFR/ErbB-2 inhibitor-1	Inhibitor	/	Unkown
HY-160068	2-2(t) aptamer sodium	Chemical	/	Unkown
HY-168577	KRAS G12D inhibitor 25	Inhibitor	/	Unkown
HY-50898S1	Lapatinib-d7 dihydrochloride		/	Unkown
HY-50898S2	Lapatinib-d5		/	Unkown
HY-50898S3	Lapatinib-d4-1		/	Unkown
HY-P4082	ErbB-2-binding peptide		99.83%	Unkown
HY-RS04466	ERBB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04467	Erbb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04468	ERBB2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W008914	(E/Z)-CP-724714	Inhibitor	/	Unkown
HY-103443A	HKI-357 dimaleate	Inhibitor	/	Unkown
HY-129288	GW837016X	Inhibitor	/	Unkown
HY-164548	WK88-1		/	Unkown
HY-50898CS	Lapatinib-d4 tosylate		/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990909	Calotatug		/	Unkown
HY-P990972	Azerutamig		/	Unkown
HY-P990978	Caxmotabart		/	Unkown
HY-P990695	Lunaxafusp	Inhibitor	/	Unkown
HY-P990697	Anvatabart	Inhibitor	/	Unkown
HY-P99558	Timigutuzumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ERBB2	NCBI	NCBI:2064
Canis familiaris	ERBB2	NCBI	NCBI:403883
Macaca fascicularis	ERBB2	NCBI	NCBI:102146608
Mus musculus	ERBB2	NCBI	NCBI:13866
Macaca mulatta	ERBB2	NCBI	NCBI:697573

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