FUNDC1 - FUN14 domain containing 1 Gene

Homo sapiens

Gene ID: 139341 | Gene type: protein coding

About FUNDC1

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:44,523,639-44,542,859 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 11.4), heart (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]

FUNDC1 Products(1)

mRNA	Protein	Name
NM_173794.4	NP_776155.1	FUN14 domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy of mitochondrion	IDA IDA: Inferred from direct assay	22267086	GOA
acts upstream of or within autophagy of mitochondrion	IGI IGI: Inferred from genetic interaction	22267086	GOA
acts upstream of or within autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	22267086	GOA
involved in mitochondrial fusion	IGI IGI: Inferred from genetic interaction	37931419	GOA
involved in mitophagy	IGI IGI: Inferred from genetic interaction	34244144	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	22267086	GOA
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	22267086	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22267086	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUNDC1 Protein Structure

FUN14

0
100
155 a.a.

Protein Preferred Names

Protein Names

FUN14 domain-containing protein 1

FUNDC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FUNDC1	Q8IVP5	SLC25A46	Homo sapiens	Q96AG3	Y2H Prey Pooling	25416956
Intra	FUNDC1	Q8IVP5	SLC25A46	Homo sapiens	Q96AG3	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	SLC25A46	Homo sapiens	Q96AG3	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	EHHADH	Homo sapiens	Q08426	Y2H Array	31515488
Intra	FUNDC1	Q8IVP5	EHHADH	Homo sapiens	Q08426	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	EHHADH	Homo sapiens	Q08426	Y2H Prey Pooling	25416956
Intra	FUNDC1	Q8IVP5	SH3GLB1	Homo sapiens	Q9Y371	Y2H Prey Pooling	25416956
Intra	FUNDC1	Q8IVP5	SNX1	Homo sapiens	Q13596	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	TUFM	Homo sapiens	P49411	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3B	Homo sapiens	Q9GZQ8	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3B	Homo sapiens	Q9GZQ8	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3B	Homo sapiens	Q9GZQ8	BiFC	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Bait CoIP	24671035
Intra	FUNDC1	Q8IVP5	YES1	Homo sapiens	P07947	Y2H Prey Pooling	25416956
Intra	FUNDC1	Q8IVP5	YES1	Homo sapiens	P07947	Y2H Array	31515488
Intra	FUNDC1	Q8IVP5	SENP2	Homo sapiens	Q9HC62	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	SENP2	Homo sapiens	Q9HC62	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	GABARAPL2	Homo sapiens	P60520	Y2H Array	31515488
Intra	FUNDC1	Q8IVP5	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3A	Homo sapiens	Q9H492	Validated Y2H	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3A	Homo sapiens	Q9H492	Y2H Prey Pooling	25416956
Intra	FUNDC1	Q8IVP5	MAP1LC3A	Homo sapiens	Q9H492	Y2H Array	25416956
Intra	FUNDC1	Q8IVP5	CTBP2	Homo sapiens	P56545	Y2H Array	25416956
Cross	FUNDC1	Q8IVP5	Ulk1	Mus musculus	O70405	Anti Tag CoIP	24671035

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05145	FUNDC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FUNDC1	VGNC	VGNC:41007
Bos taurus	FUNDC1	VGNC	VGNC:29143
Mus musculus	FUNDC1	MGD	MGI:1919268
Rattus norvegicus	FUNDC1	RGD	RGD:1563372

Name
Email *

	Sorry, but the email address you supplied was invalid.