SNX1 - sorting nexin 1 Gene

Homo sapiens

Also known as VPS5; HsT17379

Gene ID: 6642 | Gene type: protein coding

About SNX1

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,095,982-64,144,231 (from NCBI)

This gene has 14 transcripts (splice variants), 269 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 29.5), fat (RPKM 17.2) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

SNX1 Products(3)

mRNA	Protein	Name
NM_001242933.2	NP_001229862.1	sorting nexin-1 isoform d
NM_003099.5	NP_003090.2	sorting nexin-1 isoform a
NM_148955.4	NP_683758.1	sorting nexin-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11102511	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables leptin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	15498486	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables transferrin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in early endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	15498486	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	15498486	GOA
involved in lamellipodium morphogenesis	IDA IDA: Inferred from direct assay	20604901	GOA
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	20070609	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	18088323	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11279102	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	15498486	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15673616	GOA
located in membrane	IDA IDA: Inferred from direct assay	9819414	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9819414	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	19619496	GOA
part of retromer, tubulation complex	IPI IPI: Inferred from physical interaction	11102511	GOA
located in vesicle	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX1 Protein Structure

Sorting_nexin

Vps5

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

sorting nexin-1

sorting nexin 1A

SNX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNX1	Q13596	SNX2	Homo sapiens	O60749	LexA B52 Complement	11102511
Intra	SNX1	Q13596	SNX2	Homo sapiens	O60749	Anti Tag CoIP	33961781
Intra	SNX1	Q13596	SNX2	Homo sapiens	O60749	Anti Tag CoIP	28514442
Intra	SNX1	Q13596	VPS35	Homo sapiens	Q96QK1	GMS	11102511
Intra	SNX1	Q13596	VPS35	Homo sapiens	Q96QK1	LexA B52 Complement	11102511
Intra	SNX1	Q13596	HCCS	Homo sapiens	P53701	Y2H Array	32296183
Intra	SNX1	Q13596	HCCS	Homo sapiens	P53701	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	COQ3	Homo sapiens	Q9NZJ6	Validated Y2H	32296183
Intra	SNX1	Q13596	COQ3	Homo sapiens	Q9NZJ6	Y2H Array	32296183
Intra	SNX1	Q13596	COQ3	Homo sapiens	Q9NZJ6	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	SNX1	Q13596	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	SNX1	Q13596	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	SNX1	Q13596	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	SNX1	Q13596	CHRNG	Homo sapiens	P07510-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	CHRNG	Homo sapiens	P07510-2	Y2H Array	32296183
Intra	SNX1	Q13596	SYNGR1	Homo sapiens	O43759-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SYNGR1	Homo sapiens	O43759-2	Y2H Array	32296183
Intra	SNX1	Q13596	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	SNX1	Q13596	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	SNX1	Q13596	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Intra	SNX1	Q13596	REEP5	Homo sapiens	Q00765	Y2H Array	32296183
Intra	SNX1	Q13596	REEP5	Homo sapiens	Q00765	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	CMTM4	Homo sapiens	Q8IZR5-2	Validated Y2H	32296183
Intra	SNX1	Q13596	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	SNX1	Q13596	RHEX	Homo sapiens	Q6ZWK4	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	RHEX	Homo sapiens	Q6ZWK4	Validated Y2H	32296183
Intra	SNX1	Q13596	RHEX	Homo sapiens	Q6ZWK4	Y2H Array	32296183
Intra	SNX1	Q13596	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	SNX1	Q13596	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	SNX1	Q13596	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32296183
Intra	SNX1	Q13596	SH3GLB1	Homo sapiens	Q9Y371	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Y2H Array	32296183
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Validated Y2H	25416956
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Anti Tag CoIP	33961781
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Y2H	21516116
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Validated Y2H	32296183
Intra	SNX1	Q13596	SNX6	Homo sapiens	Q9UNH7	Anti Tag CoIP	33961781
Intra	SNX1	Q13596	SNX6	Homo sapiens	Q9UNH7	Anti Tag CoIP	28514442
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Y2H Prey Pooling	25416956
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SNX6	Homo sapiens	Q9UNH7	Anti Tag CoIP	35271311
Intra	SNX1	Q13596	SNX32	Homo sapiens	Q86XE0	Y2H Array	25416956
Intra	SNX1	Q13596	SNX6	Homo sapiens	Q9UNH7	Validated Y2H	32296183
Intra	SNX1	Q13596	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	SNX1	Q13596	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	SNX1	Q13596	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	SNX1	Q13596	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SFT2D1	Homo sapiens	Q8WV19	Validated Y2H	32296183
Intra	SNX1	Q13596	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
Intra	SNX1	Q13596	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
Intra	SNX1	Q13596	ARMC12	Homo sapiens	Q5T9G4-2	Validated Y2H	32296183
Intra	SNX1	Q13596	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	SNX1	Q13596	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	SNX1	Q13596	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	SDR16C5	Homo sapiens	Q8N3Y7	Validated Y2H	32296183
Intra	SNX1	Q13596	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Array	32296183
Intra	SNX1	Q13596	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	25416956
Intra	SNX1	Q13596	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	25416956
Intra	SNX1	Q13596	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	SNX1	Q13596	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	SNX1	Q13596	SNX5	Homo sapiens	Q9Y5X3	Anti Tag CoIP	33961781
Intra	SNX1	Q13596	SNX5	Homo sapiens	Q9Y5X3	Pull Down	23085988
Intra	SNX1	Q13596	SNX5	Homo sapiens	Q9Y5X3	Anti Tag CoIP	28514442
Intra	SNX1	Q13596	RTN4	Homo sapiens	Q9NQC3	Validated Y2H	25416956
Intra	SNX1	Q13596	RTN4	Homo sapiens	Q9NQC3	Y2H Array	25416956
Intra	SNX1	Q13596	MPC2	Homo sapiens	O95563	Y2H Array	32296183
Intra	SNX1	Q13596	MPC2	Homo sapiens	O95563	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	SNX1	Q13596	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	SNX1	Q13596	RTN3	Homo sapiens	O95197	Y2H Array	25416956
Intra	SNX1	Q13596	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	SNX1	Q13596	REEP6	Homo sapiens	Q96HR9	Y2H	21988832
Intra	SNX1	Q13596	REEP6	Homo sapiens	Q96HR9	Y2H Array	25416956
Intra	SNX1	Q13596	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	SNX1	Q13596	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13522	SNX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX1	RGD	RGD:68935
Canis familiaris	SNX1	VGNC	VGNC:46619
Macaca mulatta	SNX1	VGNC	VGNC:77681
Felis catus	SNX1	VGNC	VGNC:65541
Mus musculus	SNX1	MGD	MGI:1928395
Bos taurus	SNX1	VGNC	VGNC:35090

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