2. Gene
  3. POLR2A - RNA polymerase II subunit A Gene

POLR2A - RNA polymerase II subunit A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; NEDHIB; RpIILS; hsRPB1; hRPB220

Gene ID: 5430 | Gene type: protein coding

About POLR2A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,484,366-7,514,616 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 197 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 59.5), skin (RPKM 31.0) and 25 other tissues.

Summary

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several Other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

POLR2A Products(1)

mRNA Protein Name
NM_000937.5 NP_000928.1 DNA-directed RNA polymerase II subunit RPB1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-directed 5'-3' RNA polymerase activity IDA
IDA: Inferred from direct assay
9852112 GOA
enables RNA-dependent RNA polymerase activity IDA
IDA: Inferred from direct assay
23395899 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
28076779 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
27193682 GOA
enables microfibril binding EXP
EXP: Inferred from Experiment
28945358 GOA
enables microfibril binding IDA
IDA: Inferred from direct assay
28945358 GOA
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24441171 GOA
contributes to protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10075709 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17996703 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
27193682 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA-templated transcription termination IMP
IMP: Inferred from mutant phenotype
26700805 GOA
involved in positive regulation of RNA splicing IDA
IDA: Inferred from direct assay
21536736 GOA
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Prp19 complex IDA
IDA: Inferred from direct assay
21536736 GOA
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16109376 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2A Protein Structure

RNA_pol_Rpb1_1

RNA_pol_Rpb1_1: RNA polymerase Rpb1, domain 1 (16 - 354)

RNA_pol_Rpb1_2

RNA_pol_Rpb1_2: RNA polymerase Rpb1, domain 2 (356 - 521)

RNA_pol_Rpb1_3

RNA_pol_Rpb1_3: RNA polymerase Rpb1, domain 3 (525 - 691)

RNA_pol_Rpb1_4

RNA_pol_Rpb1_4: RNA polymerase Rpb1, domain 4 (718 - 823)

RNA_pol_Rpb1_5

RNA_pol_Rpb1_5: RNA polymerase Rpb1, domain 5 (830 - 1424)

RNA_pol_Rpb1_6

RNA_pol_Rpb1_6: RNA polymerase Rpb1, domain 6 (896 - 1079)

RNA_pol_Rpb1_7

RNA_pol_Rpb1_7: RNA polymerase Rpb1, domain 7 (1164 - 1299)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1594 - 1606)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1610 - 1622)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1616 - 1629)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1623 - 1636)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1630 - 1643)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1637 - 1650)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1644 - 1657)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1651 - 1664)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1658 - 1671)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1665 - 1678)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1672 - 1685)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1679 - 1692)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1686 - 1699)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1693 - 1706)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1700 - 1713)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1707 - 1720)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1714 - 1727)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1721 - 1734)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1728 - 1741)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1735 - 1748)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1742 - 1755)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1749 - 1762)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1757 - 1769)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1763 - 1776)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1770 - 1783)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1778 - 1790)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1784 - 1797)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1791 - 1804)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1798 - 1811)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1826 - 1839)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1833 - 1846)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1841 - 1853)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1847 - 1860)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1855 - 1867)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1861 - 1874)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1868 - 1881)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1875 - 1888)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1882 - 1895)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1889 - 1902)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1896 - 1909)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1904 - 1916)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1910 - 1923)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1917 - 1930)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1924 - 1936)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1931 - 1947)

RNA_pol_Rpb1_R

RNA_pol_Rpb1_R: RNA polymerase Rpb1 C-terminal repeat (1948 - 1960)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1970 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB1

DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit

POLR2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POLR2A P24928 RPRD1A Homo sapiens Q96P16
Anti Bait CoIP
24997600
Cross
POLR2A P24928 ORF6 Equid herpesvirus 1 L8B1Q7
Pull Down
24418534
Cross
POLR2A P24928 ORF6 Equid herpesvirus 1 L8B1Q7
Anti Bait CoIP
24418534
Intra
POLR2A P24928 SETX Homo sapiens Q7Z333
Anti Bait CoIP
26700805
Intra
POLR2A P24928 SETX Homo sapiens Q7Z333
Anti Tag CoIP
26700805
Intra
POLR2A P24928 DICER1 Homo sapiens Q9UPY3-1
Anti Bait CoIP
24814348
Intra
POLR2A P24928 RECQL5 Homo sapiens O94762-1
Pull Down
18562274
Intra
POLR2A P24928 RECQL5 Homo sapiens O94762-1
Anti Tag CoIP
18562274
Intra
POLR2A P24928 RECQL5 Homo sapiens O94762-1
Far-WB
18562274
Intra
POLR2A P24928 THAP3 Homo sapiens Q8WTV1
Validated Y2H
32814053
Intra
POLR2A P24928 THAP3 Homo sapiens Q8WTV1
Y2H Array
32814053
Intra
POLR2A P24928 THAP3 Homo sapiens Q8WTV1
Y2H Pooling
32814053
Intra
POLR2A P24928 MIER1 Homo sapiens Q8N108-16
Validated Y2H
32814053
Intra
POLR2A P24928 MIER1 Homo sapiens Q8N108-16
Y2H Array
32814053
Intra
POLR2A P24928 MIER1 Homo sapiens Q8N108-16
Y2H Pooling
32814053
Intra
POLR2A P24928 PAF1 Homo sapiens Q8N7H5
Anti Bait CoIP
16024656
Intra
POLR2A P24928 PAF1 Homo sapiens Q8N7H5
Anti Bait CoIP
15923622
Intra
POLR2A P24928 TCEA1 Homo sapiens P23193
Pull Down
23748380
Intra
POLR2A P24928 XAB2 Homo sapiens Q9HCS7
CoIP
10944529
Intra
POLR2A P24928 PRMT5 Homo sapiens O14744
Anti Bait CoIP
26700805
Intra
POLR2A P24928 DDX5 Homo sapiens P17844
Anti Bait CoIP
12527917
Intra
POLR2A P24928 TDRD3 Homo sapiens Q9H7E2
Anti Tag CoIP
26700805
Intra
POLR2A P24928 SMN1 Homo sapiens Q16637
Anti Tag CoIP
26700805
Intra
POLR2A P24928 SMN1 Homo sapiens Q16637
Anti Bait CoIP
26700805
Intra
POLR2A P24928 ASB6 Homo sapiens Q9NWX5
Anti Tag CoIP
33961781
Intra
POLR2A P24928 ASB6 Homo sapiens Q9NWX5
Validated Y2H
32296183
Intra
POLR2A P24928 SUPT5H Homo sapiens O00267
Anti Bait CoIP
24814348
Intra
POLR2A P24928 SNF8 Homo sapiens Q96H20
Pull Down
19819239
Intra
POLR2A P24928 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
19819239
Intra
POLR2A P24928 RPRD1B Homo sapiens Q9NQG5
Crosslink
22264791
Intra
POLR2A P24928 CDC73 Homo sapiens Q6P1J9
Anti Bait CoIP
15923622
Intra
POLR2A P24928 CDC73 Homo sapiens Q6P1J9
Anti Bait CoIP
16024656
Cross
POLR2A P24928 PA Influenza A virus Q67020
BiFC
21994455
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Hypotonia And Variable Intellectual And Behavioral Abnormalities

NEDHIB
Skull Base Meningioma

Meningioma Of The Skull Base
Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms
Fusariosis

Fusarium Infection
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
White Piedra

Tinea Blanca

Trichosporosis Nodosa
Angiomatous Meningioma
Anterior Cranial Fossa Meningioma

Meningioma Of The Anterior Fossa
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove
Psammomatous Meningioma
Rhabdoid Meningioma

Papillary Meningioma

Meningioma, Rhabdoid
Secretory Meningioma

Meningioma
Meningothelial Meningioma

Meningotheliomatous Meningioma
Cerebral Falx Meningioma

Falcine Meningioma

Falx Cerebri Meningioma
Fibrous Meningioma

Fibroblastic Meningioma
Foramen Magnum Meningioma

Meningioma Of The Foramen Magnum
Hypotonia
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Parasagittal Meningioma
Cavernous Sinus Meningioma

Meningioma Of The Cavernous Sinus
Cerebral Convexity Meningioma

Cerebral Hemispheric Convexity Meningioma
Clear Cell Meningioma
Transitional Meningioma

Transitional Meningioma
Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma
Intraventricular Meningioma
Benign Meningioma

Meningioma, Benign
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Intracranial Meningioma

Meningioma
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135646 Eleutheroside B1 Inhibitor 98.73% Unkown
HY-RS10842 POLR2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus POLR2A VGNC VGNC:33135
Mus musculus POLR2A MGD MGI:98086
Macaca mulatta POLR2A VGNC VGNC:99209
Canis familiaris POLR2A VGNC VGNC:44792
Rattus norvegicus POLR2A RGD RGD:1587326
Felis catus POLR2A VGNC VGNC:108139