NEK7 - NIMA related kinase 7 Gene

Homo sapiens

Gene ID: 140609 | Gene type: protein coding

About NEK7

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:198,156,998-198,322,420 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues.

Summary

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

NEK7 Products(1)

mRNA	Protein	Name
NM_133494.3	NP_598001.1	serine/threonine-protein kinase Nek7

NEK7 Protein Structure

Pkinase

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Nek7

NIMA (never in mitosis gene a)-related kinase 7

Recombinant NEK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75935	NEK7 Protein, Human (sf9, His-GST)	Q8TDX7-1 (M1-S302)	≥95%

Related Diseases

Diseases

Alias

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163358	SLC3037	Inhibitor	99.85%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NEK7	VGNC	VGNC:107901
Rattus norvegicus	NEK7	RGD	RGD:1311160
Mus musculus	NEK7	MGD	MGI:1890645
Macaca mulatta	NEK7	VGNC	VGNC:81484
Bos taurus	NEK7	VGNC	VGNC:31998
Canis familiaris	NEK7	VGNC	VGNC:43734
Others	NEK7	NCBI

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