1. Gene
  2. NEK7 - NIMA related kinase 7 Gene

NEK7 - NIMA related kinase 7 Gene

Homo sapiens
Gene ID: 140609 | Gene type: protein coding

About NEK7

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:198,156,998-198,322,420 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues.

Summary

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

NEK7 Products(1)

mRNA Protein Name
NM_133494.3 NP_598001.1 serine/threonine-protein kinase Nek7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular function activator activity IDA
IDA: Inferred from direct assay
19941817 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26188091 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19941817 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
31189953 GOA
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
21531765 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12840024 GOA
involved in regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
19941817 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in microtubule organizing center IDA
IDA: Inferred from direct assay
17586473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK7 Protein Structure

Pkinase

Pkinase: Protein kinase domain (34 - 288)

  • 0
  • 100
  • 200
  • 302 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek7

NIMA (never in mitosis gene a)-related kinase 7

NEK7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NEK7 Q8TDX7 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
NEK7 Q8TDX7 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
NEK7 Q8TDX7 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
NEK7 Q8TDX7 USP12 Homo sapiens O75317 32814053
Intra
NEK7 Q8TDX7 USP12 Homo sapiens O75317 32814053
Intra
NEK7 Q8TDX7 USP12 Homo sapiens O75317 32814053
Intra
NEK7 Q8TDX7 ISY1 Homo sapiens Q9ULR0 32814053
Intra
NEK7 Q8TDX7 ISY1 Homo sapiens Q9ULR0 32814053
Intra
NEK7 Q8TDX7 ISY1 Homo sapiens Q9ULR0 32814053
Intra
NEK7 Q8TDX7 MGC39372 Homo sapiens Q8TB02 32814053
Intra
NEK7 Q8TDX7 MGC39372 Homo sapiens Q8TB02 32814053
Intra
NEK7 Q8TDX7 MGC39372 Homo sapiens Q8TB02 32814053
Intra
NEK7 Q8TDX7 TMPO Homo sapiens P42166 32707033
Intra
NEK7 Q8TDX7 PGK1 Homo sapiens P00558 32707033
Intra
NEK7 Q8TDX7 DDIT4L Homo sapiens Q96D03 32296183
Intra
NEK7 Q8TDX7 DDIT4L Homo sapiens Q96D03 32296183
Intra
NEK7 Q8TDX7 DDIT4L Homo sapiens Q96D03 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEK7 Proteins

Cat. No. Product Name Accession Purity
HY-P75935 NEK7 Protein, Human (sf9, His-GST) Q8TDX7-1 (M1-S302) ≥95%

NEK7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81615 NEK7 Antibody (YA1360) WB, IP Mouse, Rat

Related Diseases

Diseases Alias
Muckle-Wells Syndrome

MWS

Urticaria-Deafness-Amyloidosis Syndrome

Uda Syndrome

Neutrophilic Urticaria

Urticaria, Deafness And Amyloidosis

Cryopyrin-Associated Periodic Syndrome 2

Caps2

Muckle Wells Syndrome

Urticaria-Deafness-Amyloidosis

Cryopyrin-Associated Periodic Syndromes

Cinca Syndrome

CINCA

Nomid

Cryopyrin-Associated Periodic Syndrome 3

Chronic Neurologic Cutaneous And Articular Syndrome

Multisystem Inflammatory Disease, Neonatal-Onset

Caps3

Chronic Infantile Neurological Cutaneous Articular Syndrome

Infantile-Onset Multisystem Inflammatory Disease

Iomid Syndrome

Neonatal-Onset Multisystem Inflammatory Disease

Nomid Syndrome

Prieur-Griscelli Syndrome

Neonatal Onset Multisystem Inflammatory Disease

Chronic Infantile Neurological, Cutaneous And Articular Syndrome

Iomid

Infantile Onset Multisystem Inflammatory Disease

Prieur Griscelli Syndrome

Chronic Infantile Neurological Cutaneous And Articular Syndrome

Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome

Chronic Infantile Neurologic Cutaneous And Articular Syndrome

Chronic Infantile Neurological, Cutaneous, And Articular Syndrome

Cryopyrin-Associated Periodic Syndromes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus NEK7 VGNC VGNC:107901
Rattus norvegicus NEK7 RGD RGD:1311160
Mus musculus NEK7 MGD MGI:1890645
Macaca mulatta NEK7 VGNC VGNC:81484
Bos taurus NEK7 VGNC VGNC:31998
Canis familiaris NEK7 VGNC VGNC:43734
Others NEK7 NCBI