2. Gene
  3. F2 - coagulation factor II Gene

F2 - coagulation factor II Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cf2; FII; Cf-2

Gene ID: 14061 | Gene type: protein coding

About F2

Summary

This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation Factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]

F2 Products(1)

mRNA Protein Name
NM_010168.3 NP_034298.1 prothrombin preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
26742564 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
18305483 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7608171 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
18398001 MGI
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
26742564 MGI
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26742564 MGI
involved in ligand-gated ion channel signaling pathway IDA
IDA: Inferred from direct assay
26742564 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: Inferred from mutant phenotype
26742564 MGI
acts upstream of or within platelet activation IDA
IDA: Inferred from direct assay
17380206 MGI
acts upstream of or within positive regulation of cell growth IGI
IGI: Inferred from genetic interaction
18398001 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18398001 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
26742564 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
26742564 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
18398001 MGI
acts upstream of or within regulation of cell shape IGI
IGI: Inferred from genetic interaction
18398001 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
16720835 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prothrombin

thrombin

Recombinant F2 Proteins

Cat. No. Product Name Accession Purity
HY-P72944 Coagulation Factor II/F2 Protein, Mouse (HEK293, His) Q3TJ94 (Q25-G618) ≥95%

F2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82008 Prothrombin Antibody (YA1753) WB, IHC-P Mouse, Rat

Related Agents

Approval
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12956 Dinoprost 99.63% Unkown
HY-B0577 Latanoprost Agonist 99.85% Unkown
HY-19518 Latanoprostene bunod Control 99.85% Unkown
HY-12956A Dinoprost tromethamine salt ≥98.0% Unkown
HY-113756A Latanoprost acid Inhibitor 99.62% Unkown
HY-128428 Carboprost 99.83% Unkown
HY-A0195 Carboprost tromethamine 99.85% Unkown
HY-106916 Unoprostone Activator ≥99.0% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown
HY-B0577R Latanoprost (Standard) Agonist / Unkown
HY-124219 17-Phenoxy trinor prostaglandin F2α ethyl amide Agonist / Unkown
HY-158571 17-Phenoxy trinor prostaglandin F2α / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-106037 PGF2α-isopropyl ester / Phase 3
HY-112284 Ebopiprant Antagonist 98.65% Phase 2
HY-17644 Redaporfin 99.44% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99712 Lonigutamab Inhibitor 95.00% Phase 2
Pre-clinical Phase
Bioactive Molecules (170)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18777 KC7F2 Inhibitor 99.36% Unkown
HY-103447 Zearalenone Activator 98.50% Unkown
HY-112904 XRK3F2 Inhibitor 99.04% Unkown
HY-15480 NSC 42834 Inhibitor 98.01% Unkown
HY-147058 SW2_152F Inhibitor 99.77% Unkown
HY-125848 Ginsenoside F2 Inducer 99.95% Unkown
HY-Y0110 2-Naphthol 99.91% Unkown
HY-107381 (+)-Cloprostenol Agonist 99.28% Unkown
HY-151810 TP0472993 Inhibitor 98.69% Unkown
HY-156190A NR2F2-IN-1 free base Inhibitor 99.34% Unkown
HY-149894 MC-1-F2 99.78% Unkown
HY-103447R Zearalenone (Standard) Activator 98.85% Unkown
HY-103462 TC-F2 Inhibitor 99.75% Unkown
HY-154992 2,4-Difluorophenylethynylcobalamin 99.73% Unkown
HY-113209 8-Isoprostaglandin F2α ≥99.0% Unkown
HY-113246 15-keto-Prostaglandin F2a 99.2% Unkown
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% Unkown
HY-E70133 Endo-β-N-acetylglucosaminidase F2 / Unkown
HY-RS04631 F2R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-103447S1 Zearalenone-13C18 98.7% Unkown
HY-111478 Tiaprost ≥98.0% Unkown
HY-113209S 8-Iso-PGF2a-d4 / Unkown
HY-118388 AS604872 Antagonist / Unkown
HY-12956S Dinoprost-d4 ≥99.0% Unkown
HY-132277S 15-Keto Bimatoprost-d5 96.65% Unkown
HY-144882 (R)-HH2853 Inhibitor / Unkown
HY-156190 NR2F2-IN-1 Inhibitor / Unkown
HY-B0577S Latanoprost-d4 Agonist ≥98.0% Unkown
HY-113208 13,14-Dihydro-15-keto Prostaglandin F2α ≥99.0% Unkown
HY-100571 Cloprostenol isopropyl ester Agonist / Unkown
HY-113208A 11β-13,14-Dihydro-15-keto Prostaglandin F2α / Unkown
HY-113208AS1 11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113209A ent-8-Iso-15(S)-prostaglandin F2α / Unkown
HY-113209S1 8-iso Prostaglandin F2α-d9 / Unkown
HY-113459S1 13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113778 15-keto-17-phenyl trinor Prostaglandin F2α / Unkown
HY-113909 Dinoprost (methoxyamine) / Unkown
HY-114593 ent-8-iso Prostaglandin F2α / Unkown
HY-114687 5,7-Dihydroxy-11-ketotetranorprostanoic acid / Unkown
HY-114695S Prostaglandin F2α-1-glyceryl ester-d5 / Unkown
HY-114761 Prostaglandin F2α dimethyl amine Antagonist / Unkown
HY-114810 Prostaglandin F2α serinol amide Agonist / Unkown
HY-114850 5-trans Prostaglandin F2β / Unkown
HY-114850A (5R)-Dinoprost tromethamine / Unkown
HY-116051 16,16-Dimethylprostaglandin F2α / Unkown
HY-116051A 16,16-Dimethylprostaglandin F2β / Unkown
HY-116161 Bimatoprost isopropyl ester / Unkown
HY-116549 Prostaglandin F2α alcohol Agonist / Unkown
HY-116591 8-Iso-15-keto prostaglandin F2β / Unkown
HY-116704 11-Deoxyprostaglandin F2α Modulator / Unkown
HY-117061 Prostaglandin F2α alcohol methyl ether Agonist / Unkown
HY-118190 AL 8810 methyl ester Agonist / Unkown
HY-118294 15-OH Tafluprost Control / Unkown
HY-118599 Prostaglandin F2α ethyl amide / Unkown
HY-118648 Prostaglandin F2α methyl ester Agonist / Unkown
HY-118816 11β-Prostaglandin F2α / Unkown
HY-120197 17-Phenyl trinor prostaglandin F2α methyl amide Inhibitor / Unkown
HY-120955 (+)-5-trans Cloprostenol Control / Unkown
HY-121314 Cloprostenol / Unkown
HY-125150 AL-3138 Antagonist / Unkown
HY-125396 11-Deoxyprostaglandin F2β / Unkown
HY-125626 8-iso-15-keto Prostaglandin F2α Agonist / Unkown
HY-125946 Latanoprost lactone diol 99.86% Unkown
HY-129397S 2,3-Dinor-11β-prostaglandin F2α-d9 / Unkown
HY-12956B (5R)-Dinoprost / Unkown
HY-12956S1 Dinoprost-d9 / Unkown
HY-12956S2 Dinoprost-13C5 / Unkown
HY-129953 9α,11β-Prostaglandin F2α / Unkown
HY-129953A 5-trans Prostaglandin F2α / Unkown
HY-129953C 5-trans Prostaglandin F2α tromethamine / Unkown
HY-129953S 9α,11β-Prostaglandin F2α-d4 / Unkown
HY-129953S1 9α,11β-Prostaglandin F2α-d9 / Unkown
HY-130660 Prostaglandin F2α ethanolamide Agonist / Unkown
HY-131617 Prostaglandin F2α 1,11-lactone Control / Unkown
HY-131632 1a,1b-Dihomo prostaglandin F2α / Unkown
HY-132277 15-Keto Bimatoprost Control / Unkown
HY-136494 Fluprostenol / Unkown
HY-137024 15-Keto-PGA1 Activator / Unkown
HY-137119 (±)5-iPF2α-VI Control / Unkown
HY-137119A 8,12-iso-iPF2α-VI Control / Unkown
HY-137412 PGF2α 1,15-lactone / Unkown
HY-137504 20-ethyl Prostaglandin F2α / Unkown
HY-137544 16-Phenyl tetranor Prostaglandin F2α / Unkown
HY-137585 17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Control / Unkown
HY-138244 8-iso Prostaglandin F2β / Unkown
HY-139063 16-Phenoxy tetranor prostaglandin F2α / Unkown
HY-139119 Prostaglandin F2α dimethyl amide Antagonist / Unkown
HY-139121 15(R)-17-Phenyl trinor Prostaglandin F2α Agonist / Unkown
HY-139124 15(R)-15-Methyl Prostaglandin F2α Agonist / Unkown
HY-149588 17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester / Unkown
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / Unkown
HY-149926 Cathepsin Inhibitor 3 / Unkown
HY-151190 cis-4-Br-2,5-F2-PCPA Inhibitor / Unkown
HY-151453 Topoisomerase IIα-IN-4 / Unkown
HY-154606 2'-F-2'-ara-N2-ibu-dG Phosphoramidite / Unkown
HY-154854 BBDDL2059 Inhibitor / Unkown
HY-157292 2E-3-F16 / Unkown
HY-158450 FA2G2 glycan (G2F), 2-AB labelled / Unkown
HY-158459 A2G2F2 glycan / Unkown
HY-158478 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled / Unkown
HY-158481 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled / Unkown
HY-158499 FA2 glycan (G0F), 2-AA labelled / Unkown
HY-158500 FA2 glycan (G0F), 2-AB labelled / Unkown
HY-158595 15(R),19(R)-Hydroxy prostaglandin F2α / Unkown
HY-158937 15(R)-15-Methyl prostaglandin F2α methyl ester Control / Unkown
HY-162142 BB2-50F Inhibitor 99.52% Unkown
HY-163376 17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide / Unkown
HY-163552 Prostaglandin F2a/BSA / Unkown
HY-163709 PROTAC FAK degrader 2 Degrader / Unkown
HY-164141 GDP-D-Rha6F2 / Unkown
HY-168890 TRF2-IN-1 / Unkown
HY-D0160 ZnAF-2F / Unkown
HY-D0161 ZnAF-2F DA / Unkown
HY-E70487 Human CYP4F2,Low-Reductase+b5 / Unkown
HY-N12119 ent-Prostaglandin F2α / Unkown
HY-N12817 Anti-inflammatory agent 80 Inhibitor / Unkown
HY-N7614 Anemarrhenasaponin A2 / Unkown
HY-R00011 hsa-let-7f-2-3p mimic / Unkown
HY-R00011A hsa-let-7f-2-3p agomir / Unkown
HY-R02559 mmu-let-7f-2-3p mimic / Unkown
HY-R02559A mmu-let-7f-2-3p agomir / Unkown
HY-RI00011 hsa-let-7f-2-3p inhibitor / Unkown
HY-RI00011A hsa-let-7f-2-3p antagomir / Unkown
HY-RI02559 mmu-let-7f-2-3p inhibitor / Unkown
HY-RI02559A mmu-let-7f-2-3p antagomir / Unkown
HY-RS03480 CYP4F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04111 E2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04630 F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04632 F2r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04633 F2r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04634 F2RL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04635 F2rl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04636 F2rl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09542 NR2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10898 POU2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10901 POU3F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10905 POU4F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10911 POU5F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10913 POU6F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13206 SLC35F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W006069 H-Phe(3,5-DiF)-OH 95.96% Unkown
HY-W399193 PGF2α 1,9-lactone Inhibitor / Unkown
HY-W746888 17-Phenyl trinor prostaglandin F2α diethyl amide / Unkown
HY-Y0110S 2-Naphthol-d8 / Unkown
HY-Y0110S1 2-Naphthol-d7 95.00% Unkown
HY-112284A Ebopiprant hydrochloride Antagonist / Unkown
HY-113209S2 8-Isoprostaglandin F2α-13C5 / Unkown
HY-114695 Prostaglandin F2α-1-glyceryl ester / Unkown
HY-114841 ONO 207 / Unkown
HY-116679 17-trifluoromethylphenyl trinor Prostaglandin F2α / Unkown
HY-116889 15-Keto latanoprost acid / Unkown
HY-118520 16-Phenoxy tetranor prostaglandin F2α methyl ester / Unkown
HY-120982 (+)-15-epi Cloprostenol / Unkown
HY-124175 16-Phenoxy prostaglandin F2α ethyl amide / Unkown
HY-124243 N-Cyclopropyl methyl bimatoprost Agonist / Unkown
HY-137547 20-Hydroxy-PGF2α / Unkown
HY-149554 17-Phenyl trinor Prostaglandin F2α dimethyl amide / Unkown
HY-149749 Methylthiomcresol-C3-COOH / Unkown
HY-N8085 Icariside F2 Inhibitor / Unkown
HY-W408869 8-iso-13,14-dihydro-15-keto Prostaglandin F2α / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W701877 Latanoprost tris(triethylsilyl) ether Control / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990597 HuGAL-F2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2 NCBI NCBI:2147
Canis familiaris F2 NCBI NCBI:100856539
Felis catus F2 NCBI NCBI:101090463
Macaca fascicularis F2 NCBI NCBI:102131020
Susscrofa domestica F2 NCBI
Leporidae F2 NCBI
Rattus norvegicus F2 NCBI NCBI:29251
Macaca mulatta F2 NCBI NCBI:712729