Fas - Fas (TNF receptor superfamily member 6) Gene

Mus musculus

Also known as lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6

Gene ID: 14102 | Gene type: protein coding

About Fas

Summary

Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic Cancer (multiple); pre-eclampsia (multiple); and urinary system Cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fas Products(2)

mRNA	Protein	Name
NM_001146708.1	NP_001140180.1	tumor necrosis factor receptor superfamily member 6 isoform 2 precursor
NM_007987.2	NP_032013.2	tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	8524870	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7536190	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell mediated immunity	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	8640868	MGI
acts upstream of or within activation-induced cell death of T cells	IDA IDA: Inferred from direct assay	12702495	MGI
acts upstream of or within activation-induced cell death of T cells	IMP IMP: Inferred from mutant phenotype	7602121	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	8700551	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: Inferred from direct assay	7511063	MGI
acts upstream of or within cellular response to lithium ion	IMP IMP: Inferred from mutant phenotype	20530871	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	12011074	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	13679421	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	8524870	MGI
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10950869	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: Inferred from genetic interaction	12431371	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	8524870	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	7602121	MGI
acts upstream of or within hepatocyte apoptotic process	IGI IGI: Inferred from genetic interaction	20436477	MGI
acts upstream of or within immunoglobulin production	IMP IMP: Inferred from mutant phenotype	18199416	MGI
acts upstream of or within inflammatory cell apoptotic process	IDA IDA: Inferred from direct assay	12801066	MGI
acts upstream of or within inflammatory cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12801066	MGI
acts upstream of or within lymphocyte apoptotic process	IDA IDA: Inferred from direct assay	15632112	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	13679421	MGI
acts upstream of or within necroptotic signaling pathway	IGI IGI: Inferred from genetic interaction	21052097	MGI
acts upstream of or within negative regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	6610701	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	7595210	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	10429671	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20530871	MGI
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	10950869	MGI
acts upstream of or within regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	6610701	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	6610701	MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	9697835	MGI
acts upstream of or within regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	9697835	MGI
acts upstream of or within response to glucocorticoid	IMP IMP: Inferred from mutant phenotype	7602121	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	8557033	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	18199416	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	20935634	MGI
located in cell surface	IDA IDA: Inferred from direct assay	7595210	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8788039	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	7595210	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 6

FASLG receptor	Fas (TNF receptor superfamily member)
Fas antigen	apo-1 antigen
apoptosis-mediating surface antigen FAS	lymphoproliferation

Recombinant Fas Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70330	Fas/CD95 Protein, Mouse (HEK293, His)	P25446 (Q22-R169)	≥95%
HY-P78296	Fas/CD95 Protein, Mouse (HEK293, Fc)	P25446 (Q22-R169)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13721	Phenoxodiol		99.76%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12325	GSK2194069	Inhibitor	99.84%	Unkown
HY-14414	GSK4112	Inhibitor	99.87%	Unkown
HY-133897	(Rac)-Indoximod		98.13%	Unkown
HY-150190	F5446		99.38%	Unkown
HY-16100	BI 99179	Inhibitor	99.38%	Unkown
HY-100755	KR-33493	Inhibitor	99.75%	Unkown
HY-103243	TCPOBOP	Inhibitor	98.67%	Unkown
HY-101849	Fasentin		≥98.0%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-N0686	Pseudoprotodioscin	Inhibitor	98.76%	Unkown
HY-P10102	Kp7-6	Inhibitor	99.77%	Unkown
HY-103348	Boc-Asp(OMe)-fluoromethyl ketone	Inhibitor	≥98.0%	Unkown
HY-Y0598	trans-Chalcone		98.65%	Unkown
HY-112716	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	Inhibitor	≥99.0%	Unkown
HY-129624A	Bisindolylmaleimide VIII acetate		99.68%	Unkown
HY-108610A	Edelfosine	Inducer	≥98.0%	Unkown
HY-N6777	Penicillic acid	Inhibitor	99.83%	Unkown
HY-N7930	Crenulatin		≥99.0%	Unkown
HY-103347	M50054	Inhibitor	98.44%	Unkown
HY-103323	Fas C-Terminal Tripeptide	Inhibitor	/	Unkown
HY-113963	Ac-IETD-CHO	Inhibitor	/	Unkown
HY-118147	ML356	Inhibitor	/	Unkown
HY-146197	Apoptotic agent-1	Inducer	/	Unkown
HY-167879	(Rac)-NPD6433	Inhibitor	/	Unkown
HY-P3779	Amyloid 17-42	Inducer	/	Unkown
HY-P5798	Fasciculin-I	Inhibitor	/	Unkown
HY-RS04751	FAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-129624	Bisindolylmaleimide VIII		/	Unkown
HY-167879A	NPD6433	Inhibitor	/	Unkown
HY-P10401	TAT-GluR6-9c	Antagonist	/	Unkown
HY-P5797	Fasciculin-II	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99133	Anti-Mouse Fas Ligand Antibody (MFL3)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fas	NCBI	NCBI:355
Macaca fascicularis	Fas	NCBI	NCBI:102140989
Rattus norvegicus	Fas	NCBI	NCBI:246097

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