2. Gene
  3. Fas - Fas (TNF receptor superfamily member 6) Gene

Fas - Fas (TNF receptor superfamily member 6) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6

Gene ID: 14102 | Gene type: protein coding

About Fas

Summary

Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic Cancer (multiple); pre-eclampsia (multiple); and urinary system Cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fas Products(2)

mRNA Protein Name
NM_001146708.1 NP_001140180.1 tumor necrosis factor receptor superfamily member 6 isoform 2 precursor
NM_007987.2 NP_032013.2 tumor necrosis factor receptor superfamily member 6 isoform 1 precursor
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 6

FASLG receptor

Fas (TNF receptor superfamily member)

Fas antigen

apo-1 antigen

apoptosis-mediating surface antigen FAS

lymphoproliferation

Recombinant Fas Proteins

Cat. No. Product Name Accession Purity
HY-P70330 Fas/CD95 Protein, Mouse (HEK293, His) P25446 (Q22-R169) ≥95%
HY-P78296 Fas/CD95 Protein, Mouse (HEK293, Fc) P25446 (Q22-R169) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13721 Phenoxodiol 99.76% Phase 3
Pre-clinical Phase
Bioactive Molecules (29)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12325 GSK2194069 Inhibitor 99.84% Unkown
HY-14414 GSK4112 Inhibitor 99.87% Unkown
HY-133897 (Rac)-Indoximod 98.13% Unkown
HY-150190 F5446 99.38% Unkown
HY-100755 KR-33493 Inhibitor 99.75% Unkown
HY-103243 TCPOBOP Inhibitor 98.67% Unkown
HY-16100 BI 99179 Inhibitor 99.38% Unkown
HY-101849 Fasentin ≥98.0% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 98.76% Unkown
HY-P10102 Kp7-6 Inhibitor 99.77% Unkown
HY-Y0598 trans-Chalcone 98.65% Unkown
HY-103348 Boc-Asp(OMe)-fluoromethyl ketone Inhibitor ≥98.0% Unkown
HY-112716 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride Inhibitor ≥99.0% Unkown
HY-129624A Bisindolylmaleimide VIII acetate 99.68% Unkown
HY-N6777 Penicillic acid Inhibitor 99.83% Unkown
HY-108610A Edelfosine Inducer ≥98.0% Unkown
HY-103347 M50054 Inhibitor 98.44% Unkown
HY-N7930 Crenulatin ≥99.0% Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-113963 Ac-​IETD-​CHO Inhibitor / Unkown
HY-146197 Apoptotic agent-1 Inducer / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P5798 Fasciculin-I Inhibitor / Unkown
HY-RS04751 FAS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118147 ML356 Inhibitor / Unkown
HY-129624 Bisindolylmaleimide VIII / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown
HY-P5797 Fasciculin-II Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99133 Anti-Mouse Fas Ligand Antibody (MFL3) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fas NCBI NCBI:355
Macaca fascicularis Fas NCBI NCBI:102140989
Rattus norvegicus Fas NCBI NCBI:246097