2. Gene
  3. UNC93B1 - unc-93 homolog B1, TLR signaling regulator Gene

UNC93B1 - unc-93 homolog B1, TLR signaling regulator Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IIAE1; UNC93; UNC93B; Unc-93B1

Gene ID: 81622 | Gene type: protein coding

About UNC93B1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,991,100-68,004,097 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in spleen (RPKM 27.3), lung (RPKM 14.0) and 24 other tissues.

Summary

This gene encodes a protein that is involved in innate and adaptive immune response by regulating Toll-like Receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

UNC93B1 Products(1)

mRNA Protein Name
NM_030930.4 NP_112192.2 protein unc-93 homolog B1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Toll-like receptor binding IPI
IPI: Inferred from physical interaction
33432245 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22164301 GOA
Biological Process GO Annotation Evidence Reference Source
involved in toll-like receptor 3 signaling pathway IMP
IMP: Inferred from mutant phenotype
18082565 GOA
involved in toll-like receptor 7 signaling pathway IMP
IMP: Inferred from mutant phenotype
19006693 GOA
involved in toll-like receptor 9 signaling pathway IMP
IMP: Inferred from mutant phenotype
19006693 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18082565 GOA
located in endosome IDA
IDA: Inferred from direct assay
21642595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC93B1 Protein Structure

UNC-93

UNC-93: Ion channel regulatory protein UNC-93 (122 - 188)

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  • 596 a.a.
Protein Preferred Names Protein Names

protein unc-93 homolog B1

unc-93 related protein

UNC93B1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UNC93B1 Q9H1C4 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 FFAR3 Homo sapiens O14843
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 FFAR3 Homo sapiens O14843
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Cross
UNC93B1 Q9H1C4 ns7b_sars2 SARS-CoV-2 P0DTD8
Pull Down
33845483
Intra
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 CSE1L Homo sapiens P55060
Pull Down
30833792
Intra
UNC93B1 Q9H1C4 KPNB1 Homo sapiens Q14974
Pull Down
30833792
Intra
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
UNC93B1 Q9H1C4 CCDC107 Homo sapiens Q8WV48
Y2H Array
32296183
Intra
UNC93B1 Q9H1C4 CCDC107 Homo sapiens Q8WV48
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Encephalopathy, Acute, Infection-Induced 1

Herpes Simplex Encephalitis, Susceptibility To, 1

IIAE1

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 1

Herpes Simplex Encephalitis 1

Encephalopathy, Acute, Infection-Induced, 1, Herpes-Specific

Encephalopathy, Acute, Infection-Induced, 1

Hse1

Infection-Induced Acute Encephalopathy 1
Herpes Simplex Encephalitis

Hse

Hsv Encephalitis

Hsve

Herpes Simplex Meningo-Encephalitis

Herpes Simplex Neuroinvasion

Herpes Simplex Virus Encephalitis

Herpetic Encephalitis

Herpes Encephalitis

Herpes Simplex Virus 1 Encephalitis
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Melkersson-Rosenthal Syndrome

Melkersson Syndrome

Mros

Mrs

Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal

Melkersson'S Syndrome

Cheilitis Granulomatosa

Granulomatous Cheilitis
Immunodeficiency 31b

IMD31B

Immunodeficiency 31b, Mycobacterial And Viral Infections, Autosomal Recessive

Autosomal Recessive Stat1 Deficiency

Predisposition To Severe Viral Infection Due To Stat1 Deficiency

Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency

Stat1 Deficiency, Autosomal Recessive

Autosomal Recessive Immunodeficiency 31b, Mycobacterial And Viral Infections

Stat1 Deficiency

Autosomal Recessive Susceptibility To Mycobacterial And Viral Infections

Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency

Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive
Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis
Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy

Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy

Ane

Acute Necrotizing Encephalopathy Type 1

Adane

Ane1

Autosomal Dominant Acute Necrotizing Encephalopathy

Iiae3

Susceptibility To Acute Necrotizing Encephalopathy

Susceptibility To Infection-Induced Acute Encephalopathy

Encephalopathy, Acute Necrotizing, Susceptibility To

Encephalitis, Acute Necrotizing
Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2

FHL2

Hplh2

Hlh2

Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To

Lymphohistiocytosis, Hemophagocytic, Familial, Type 2
X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked

Imd74

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

Tlr7 Deficiency

X-Linked Immunodeficiency 74,Covid-19-Related
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15476 UNC93B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UNC93B1 MGD MGI:1859307
Canis familiaris UNC93B1 VGNC VGNC:49636
Macaca mulatta UNC93B1 VGNC VGNC:78927
Bos taurus UNC93B1 VGNC VGNC:49587
Felis catus UNC93B1 VGNC VGNC:66836
Rattus norvegicus UNC93B1 RGD RGD:1311984