NRG4 - neuregulin 4 Gene

Homo sapiens

Also known as HRG4

Gene ID: 145957 | Gene type: protein coding

About NRG4

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,935,393-76,060,240 (from NCBI)

This gene has 16 transcripts (splice variants), 103 orthologues and 3 paralogues. Ubiquitous expression in prostate (RPKM 2.0), skin (RPKM 1.9) and 25 other tissues.

Summary

The Neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

NRG4 Products(1)

mRNA	Protein	Name
NM_138573.4	NP_612640.1	pro-neuregulin-4, membrane-bound isoform

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	23033483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pro-neuregulin-4, membrane-bound isoform

heregulin 4

NRG4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NRG4	Q8WWG1	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	NRG4	Q8WWG1	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	NRG4	Q8WWG1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	NRG4	Q8WWG1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	NRG4	Q8WWG1	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	NRG4	Q8WWG1	FATE1	Homo sapiens	Q969F0	Y2H	21516116
Intra	NRG4	Q8WWG1	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	NRG4	Q8WWG1	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	NRG4	Q8WWG1	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	NRG4	Q8WWG1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	NRG4	Q8WWG1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	NRG4	Q8WWG1	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRG4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76524	Neuregulin-4/NRG4 Protein, Human	Q8WWG1 (GP&P2-F62)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09569	NRG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NRG4	VGNC	VGNC:84411
Rattus norvegicus	NRG4	RGD	RGD:1589860
Felis catus	NRG4	VGNC	VGNC:80904
Mus musculus	NRG4	MGD	MGI:1933833
Others	NRG4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.