COMMD7 - COMM domain containing 7 Gene

Homo sapiens

Also known as C20orf92; dJ1085F17.3

Gene ID: 149951 | Gene type: protein coding

About COMMD7

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,702,699-32,743,467 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 17.9), placenta (RPKM 13.5) and 25 other tissues.

Summary

Enables NF-kappaB binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription, DNA-templated; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

COMMD7 Products(2)

mRNA	Protein	Name
NM_001099339.2	NP_001092809.1	COMM domain-containing protein 7 isoform 2
NM_053041.3	NP_444269.2	COMM domain-containing protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IDA IDA: Inferred from direct assay	15799966	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15799966	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15799966	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	15799966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD7 Protein Structure

COMM_domain

0
100
200 a.a.

Protein Preferred Names

Protein Names

COMM domain-containing protein 7

COMMD7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COMMD7	Q86VX2	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD7	Q86VX2	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	37172566
Intra	COMMD7	Q86VX2	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	37172566
Intra	COMMD7	Q86VX2	CCDC22	Homo sapiens	O60826	Pull Down	23563313
Intra	COMMD7	Q86VX2	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	37172566

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03014	COMMD7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	COMMD7	VGNC	VGNC:27587
Canis familiaris	COMMD7	VGNC	VGNC:39497
Rattus norvegicus	COMMD7	RGD	RGD:1307786
Macaca mulatta	COMMD7	VGNC	VGNC:81182
Mus musculus	COMMD7	MGD	MGI:1914197

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