2. Gene
  3. COMMD7 - COMM domain containing 7 Gene

COMMD7 - COMM domain containing 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as C20orf92; dJ1085F17.3

Gene ID: 149951 | Gene type: protein coding

About COMMD7

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,702,699-32,743,467 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 17.9), placenta (RPKM 13.5) and 25 other tissues.

Summary

Enables NF-kappaB binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription, DNA-templated; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

COMMD7 Products(2)

mRNA Protein Name
NM_001099339.2 NP_001092809.1 COMM domain-containing protein 7 isoform 2
NM_053041.3 NP_444269.2 COMM domain-containing protein 7 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IDA
IDA: Inferred from direct assay
15799966 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15799966 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15799966 GOA
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
15799966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD7 Protein Structure

COMM_domain

COMM_domain: COMM domain (20 - 198)

  • 0
  • 100
  • 200 a.a.
Protein Preferred Names Protein Names

COMM domain-containing protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03014 COMMD7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus COMMD7 VGNC VGNC:27587
Canis familiaris COMMD7 VGNC VGNC:39497
Rattus norvegicus COMMD7 RGD RGD:1307786
Macaca mulatta COMMD7 VGNC VGNC:81182
Mus musculus COMMD7 MGD MGI:1914197