CCDC93 - coiled-coil domain containing 93 Gene

Homo sapiens

Gene ID: 54520 | Gene type: protein coding

About CCDC93

This gene has 9 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in bone marrow (RPKM 7.7), testis (RPKM 7.6) and 25 other tissues.

Summary

Involved in Golgi to plasma membrane transport and endocytic recycling. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

CCDC93 Products(1)

mRNA	Protein	Name
NM_019044.5	NP_061917.3	coiled-coil domain-containing protein 93

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25355947	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane transport	IMP IMP: Inferred from mutant phenotype	25355947	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	28892079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC93 Protein Structure

KOG2701

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

coiled-coil domain-containing protein 93

CCDC93 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCDC93	Q567U6	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD6	Homo sapiens	Q7Z4G1	Anti Bait CoIP	25355947
Intra	CCDC93	Q567U6	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Pull Down	37172566
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	IF	25355947
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	37172566
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Anti Bait CoIP	25355947
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	25355947
Intra	CCDC93	Q567U6	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD7	Homo sapiens	Q86VX2	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD10	Homo sapiens	Q9Y6G5	Pull Down	37172566
Intra	CCDC93	Q567U6	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	WASHC2A	Homo sapiens	Q641Q2	Anti Bait CoIP	25355947
Intra	CCDC93	Q567U6	WASHC2A	Homo sapiens	Q641Q2	Pull Down	25355947
Intra	CCDC93	Q567U6	WASHC2A	Homo sapiens	Q641Q2	SPR	25355947
Intra	CCDC93	Q567U6	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	25355947
Intra	CCDC93	Q567U6	CCDC22	Homo sapiens	O60826	Anti Bait CoIP	25355947
Intra	CCDC93	Q567U6	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	DENND10	Homo sapiens	Q8TCE6	Anti Tag CoIP	35271311
Intra	CCDC93	Q567U6	DENND10	Homo sapiens	Q8TCE6	Anti Tag CoIP	37172566
Intra	CCDC93	Q567U6	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	26496610
Intra	CCDC93	Q567U6	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome 1

3c Syndrome	Craniocerebellocardiac Dysplasia
RTSC1	Dandy-Walker-Like Malformation With Atrioventricular Septal Defect
Dandy-Walker Like Malformation With Atrioventricular Septal Defect	Cranio-Cerebello-Cardiac Dysplasia
Dandy-Walker-Like Malformation With Asd	Ritscher Schinzel Syndrome
Ritscher-Schinzel Cranio-Cerebello-Cardiac Syndrome	Ritscher-Schinzel Syndrome
3c

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Spinal Muscular Atrophy, Distal, X-Linked 3

SMAX3	Dsmax
X-Linked Distal Spinal Muscular Atrophy Type 3	X-Linked Distal Spinal Muscular Atrophy 3
Atp7a-Related Distal Motor Neuropathy	X-Linked Dhmn3
X-Linked Distal Hereditary Motor Neuropathy Type 3	X-Linked Dsma3
Spinal Muscular Atrophy, Distal, X-Linked Recessive	X-Linked Recessive Distal Spinal Muscular Atrophy
Distal Spinal Muscular Atrophy, X-Linked, 3	DSMAX3
Spinal Muscular Atrophy Distal X-Linked Recessive	Atrophy, Muscular, Spinal, Distal, X-Linked, Type 3

Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

Mednik Syndrome	Erythrokeratodermia Variabilis 3
MEDNIK	Ekv3
Erythrokeratodermia Variabilis, Kamouraska Type	Mental Retardation, Enteropathy, Deafness, Neuropathy, Ichthyosis, Keratodermia
Intellectual Disability-Enteropathy-Deafness-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome	Intellectual Disability-Enteropathy-Hearing Loss-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome
Intellectual Disability, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma	Erythrokeratodermia Variabilis Kamouraska Type
Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, Keratoderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02068	CCDC93 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCDC93	RGD	RGD:1560504
Bos taurus	CCDC93	VGNC	VGNC:26934
Mus musculus	CCDC93	MGD	MGI:1918079
Canis familiaris	CCDC93	VGNC	VGNC:38874
Macaca mulatta	CCDC93	VGNC	VGNC:84223
Felis catus	CCDC93	VGNC	VGNC:60530

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