1. Gene
  2. Hr - lysine demethylase and nuclear receptor corepressor Gene

Hr - lysine demethylase and nuclear receptor corepressor Gene

Mus musculus

Also known as hr; bldy; ALUNC; rh-bmh

Gene ID: 15460 | Gene type: protein coding

About Hr

Summary

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including Thyroid Hormone Receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory ORF that exists upstream of the primary ORF. Mutations in this upstream ORF, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]

Hr Products(2)

mRNA Protein Name
NM_001379479.1 NP_001366408.1 lysine-specific demethylase hairless
NM_021877.3 NP_068677.2 lysine-specific demethylase hairless
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11641275 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
11641275 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11641275 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear body IDA
IDA: Inferred from direct assay
11641275 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase hairless

[histone H3]-dimethyl-L-lysine(9) demethylase hairless

hairless

protein hairless

Orthologs Information

Species Symbol Source ID
Homo sapiens Hr NCBI NCBI:55806
Canis familiaris Hr NCBI NCBI:486130
Macaca fascicularis Hr NCBI NCBI:102146603
Canis lupus familiaris Hr NCBI
Susscrofa domestica Hr NCBI
Rattus norvegicus Hr NCBI NCBI:60563
Macaca mulatta Hr NCBI NCBI:574164