HR - HR lysine demethylase and nuclear receptor corepressor Gene

Homo sapiens

Also known as AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165

Gene ID: 55806 | Gene type: protein coding

About HR

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,114,419-22,131,052 (from NCBI)

This gene has 9 transcripts (splice variants), 107 orthologues, 3 paralogues and is associated with 7 phenotypes. Biased expression in skin (RPKM 28.2), esophagus (RPKM 5.5) and 8 other tissues.

Summary

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including Thyroid Hormone Receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, Other Diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

HR Products(2)

mRNA	Protein	Name
NM_005144.5	NP_005135.2	lysine-specific demethylase hairless isoform a
NM_018411.4	NP_060881.2	lysine-specific demethylase hairless isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HR Protein Structure

JmjC

0
200
400
600
800
1000
1189 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase hairless

[histone H3]-dimethyl-L-lysine(9) demethylase hairless

HR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HR	O43593	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	HR	O43593	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	HR	O43593	KLHL20	Homo sapiens	Q9BS75	Y2H Prey Pooling	32296183
Intra	HR	O43593	KLHL20	Homo sapiens	Q9BS75	Y2H Array	32296183
Intra	HR	O43593	KLHL20	Homo sapiens	Q9BS75	Validated Y2H	32296183
Intra	HR	O43593	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	HR	O43593	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	HR	O43593	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	HR	O43593	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	HR	O43593	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	HR	O43593	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	HR	O43593	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	HR	O43593	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	HR	O43593	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	HR	O43593	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	HR	O43593	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	HR	O43593	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	HR	O43593	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	HR	O43593	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	HR	O43593	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	HR	O43593	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	HR	O43593	SPRY3	Homo sapiens	O43610	Y2H Array	32296183
Intra	HR	O43593	SPRY3	Homo sapiens	O43610	Validated Y2H	32296183
Intra	HR	O43593	SPRY3	Homo sapiens	O43610	Y2H Prey Pooling	32296183
Intra	HR	O43593	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	HR	O43593	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	HR	O43593	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	HR	O43593	RBP3	Homo sapiens	P10745	Validated Y2H	32296183
Intra	HR	O43593	RBP3	Homo sapiens	P10745	Y2H Prey Pooling	32296183
Intra	HR	O43593	RBP3	Homo sapiens	P10745	Y2H Array	32296183
Intra	HR	O43593	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32296183
Intra	HR	O43593	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	HR	O43593	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	HR	O43593	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	HR	O43593	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	HR	O43593	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	HR	O43593	CNFN	Homo sapiens	Q9BYD5	Y2H Array	32296183
Intra	HR	O43593	CNFN	Homo sapiens	Q9BYD5	Validated Y2H	32296183
Intra	HR	O43593	CNFN	Homo sapiens	Q9BYD5	Y2H Prey Pooling	32296183
Intra	HR	O43593	AMMECR1	Homo sapiens	Q9Y4X0-3	Validated Y2H	32296183
Intra	HR	O43593	AMMECR1	Homo sapiens	Q9Y4X0-3	Y2H Prey Pooling	32296183
Intra	HR	O43593	AMMECR1	Homo sapiens	Q9Y4X0-3	Y2H Array	32296183
Intra	HR	O43593	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	HR	O43593	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	HR	O43593	GEMIN4	Homo sapiens	P57678	Validated Y2H	32296183
Intra	HR	O43593	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	HR	O43593	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HR	O43593	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HR	O43593	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	HR	O43593	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	HR	O43593	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	HR	O43593	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	HR	O43593	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	HR	O43593	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32296183
Intra	HR	O43593	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	HR	O43593	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	HR	O43593	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	HR	O43593	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	HR	O43593	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	HR	O43593	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	HR	O43593	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	HR	O43593	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
Intra	HR	O43593	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	HR	O43593	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Atrichia With Papular Lesions

Papular Atrichia	APL
Congenital Atrichia

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

Marie Unna Congenital Hypotrichosis

Marie Unna Hereditary Hypotrichosis	Hypotrichosis, Marie Unna Type
Muhh

Alopecia

Hypotrichosis

Alopecia, Congenital

Congenital Alopecia

ALPC

Telogen Effluvium

Van Der Woude Syndrome

Lip-Pit Syndrome	Vws
Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip	Vdws
Lps	Lip Pit Syndrome
Cleft Lip/Palate With Mucous Cysts Of Lower Lip	Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50767	Palbociclib	Inhibitor	99.94%	Unkown
HY-50767A	Palbociclib monohydrochloride	Inhibitor	99.98%	Unkown
HY-A0065	Palbociclib isethionate	Inhibitor	99.99%	Unkown
HY-50767C	Palbociclib hydrochloride	Inhibitor	99.93%	Unkown
HY-A0088A	Cefotaxime	Inhibitor	98.69%	Unkown
HY-114778	Fluzoparib	Inhibitor	99.85%	Unkown
HY-A0088	Cefotaxime sodium	Inhibitor	99.25%	Unkown
HY-B1824	Cefpirome sulfate	Inhibitor	99.49%	Unkown
HY-50767B	Palbociclib dihydrochloride	Inhibitor	/	Unkown
HY-50767D	Palbociclib orotate	Inhibitor	/	Unkown
HY-B1448A	Benidipine	Inhibitor	/	Unkown
HY-B0699	Cefpirome		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W187305	MASM7		99.56%	Unkown
HY-116770	PFM01	Inhibitor	99.68%	Unkown
HY-114842	TDRL-551	Inhibitor	99.84%	Unkown
HY-N0252	Catharanthine	Inhibitor	99.65%	Unkown
HY-N0272	Eleutheroside E	Inhibitor	99.58%	Unkown
HY-148078	PFM03	Inhibitor	98.04%	Unkown
HY-12475	Mutant IDH1-IN-1	Inhibitor	99.43%	Unkown
HY-161430	RTx-161		≥98.0%	Unkown
HY-126972A	RI(dl)-2 TFA	Inhibitor	98.02%	Unkown
HY-W052011	Ruzinurad	Inhibitor	99.26%	Unkown
HY-101813	Laflunimus	Inhibitor	99.76%	Unkown
HY-162384	EPIC-0628	Inhibitor	98.93%	Unkown
HY-N0252A	Catharanthine Tartrate	Inhibitor	98.88%	Unkown
HY-N0252B	Catharanthine Sulfate	Inhibitor	/	Unkown
HY-P3492	SARS-CoV-2-IN-34	Inhibitor	/	Unkown
HY-106076	REV 2871	Inhibitor	/	Unkown
HY-115447	Clobenpropit	Antagonist	/	Unkown
HY-117715	CK-3197		/	Unkown
HY-126972	RI(dl)-2	Inhibitor	/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-144773A	Loxoprofenol-SRS tromethamine	Inhibitor	/	Unkown
HY-146194	NHEJ inhibitor-1	Activator	/	Unkown
HY-149972	Antitumor agent-96	Inducer	/	Unkown
HY-159091	HIV-1 integrase inhibitor 12	Inhibitor	/	Unkown
HY-161431	RTx-152		/	Unkown
HY-162376	T3SS-IN-4	Inhibitor	/	Unkown
HY-163090	HR488B		/	Unkown
HY-P1807	Mast Cell Degranulating Peptide HR-2		/	Unkown
HY-P2717	Ac-YVAD-AMC	Inhibitor	/	Unkown
HY-P5497	C34 peptide	Inhibitor	/	Unkown
HY-RS06353	HR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124823	Monastroline		/	Unkown
HY-139121	15(R)-17-Phenyl trinor Prostaglandin F2α		/	Unkown
HY-157322	SAV13		/	Unkown
HY-158733	HR68		/	Unkown
HY-A0088S	Cefotaxime-d3 sodium	Inhibitor	/	Unkown
HY-W654305	Palbociclib-d4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HR	VGNC	VGNC:41781
Macaca mulatta	HR	VGNC	VGNC:73518
Bos taurus	HR	VGNC	VGNC:29950
Felis catus	HR	VGNC	VGNC:67643
Rattus norvegicus	HR	RGD	RGD:620634
Mus musculus	HR	MGD	MGI:96223
Macaca fascicularis	HR	NCBI	NCBI:102146603
Canis lupus familiaris	HR	NCBI
Susscrofa domestica	HR	NCBI
Others	HR	NCBI

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