Hr - HR, lysine demethylase and nuclear receptor corepressor Gene

Rattus norvegicus

Gene ID: 60563 | Gene type: protein coding

About Hr

Summary

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including Thyroid Hormone Receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]

Hr Products(1)

mRNA	Protein	Name
NM_024364.3	NP_077340.3	lysine-specific demethylase hairless

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	11641275	RGD
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	11641275	RGD
enables nuclear vitamin D receptor binding	IPI IPI: Inferred from physical interaction	12847098	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12847098	RGD
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11641275	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11641275	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11641275	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lysine-specific demethylase hairless

[histone H3]-dimethyl-L-lysine(9) demethylase hairless	hair growth associated
hairless homolog	hairless protein
protein hairless

Related Agents

Approval

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50767	Palbociclib	Inhibitor	99.94%	Unkown
HY-50767A	Palbociclib monohydrochloride	Inhibitor	99.98%	Unkown
HY-A0065	Palbociclib isethionate	Inhibitor	99.99%	Unkown
HY-50767C	Palbociclib hydrochloride	Inhibitor	99.93%	Unkown
HY-A0088A	Cefotaxime	Inhibitor	98.69%	Unkown
HY-114778	Fluzoparib	Inhibitor	99.96%	Unkown
HY-A0088	Cefotaxime sodium	Inhibitor	99.25%	Unkown
HY-B1824	Cefpirome sulfate	Inhibitor	99.49%	Unkown
HY-50767B	Palbociclib dihydrochloride	Inhibitor	/	Unkown
HY-50767D	Palbociclib orotate	Inhibitor	/	Unkown
HY-B1448A	Benidipine	Inhibitor	/	Unkown
HY-B0699	Cefpirome		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W187305	MASM7		99.85%	Unkown
HY-116770	PFM01	Inhibitor	99.91%	Unkown
HY-114842	TDRL-551	Inhibitor	99.84%	Unkown
HY-N0252	Catharanthine	Inhibitor	99.65%	Unkown
HY-N0272	Eleutheroside E	Inhibitor	99.58%	Unkown
HY-148078	PFM03	Inhibitor	98.04%	Unkown
HY-12475	Mutant IDH1-IN-1	Inhibitor	99.43%	Unkown
HY-161430	RTx-161		≥98.0%	Unkown
HY-101813	Laflunimus	Inhibitor	99.76%	Unkown
HY-162384	EPIC-0628	Inhibitor	98.93%	Unkown
HY-126972A	RI(dl)-2 TFA	Inhibitor	98.02%	Unkown
HY-W052011	Ruzinurad	Inhibitor	99.26%	Unkown
HY-161431	RTx-152		99.71%	Unkown
HY-N0252A	Catharanthine Tartrate	Inhibitor	98.88%	Unkown
HY-N0252B	Catharanthine Sulfate	Inhibitor	/	Unkown
HY-P10895	HR97 TFA		/	Unkown
HY-W654101	Cefotaxime-d3	Inhibitor	98.00%	Unkown
HY-P3492	SARS-CoV-2-IN-34	Inhibitor	/	Unkown
HY-106076	REV 2871	Inhibitor	/	Unkown
HY-115447	Clobenpropit	Antagonist	/	Unkown
HY-117715	CK-3197	Inhibitor	/	Unkown
HY-126972	RI(dl)-2	Inhibitor	/	Unkown
HY-129934S	Latanoprost ethyl amide-d4		/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-144773A	Loxoprofenol-SRS tromethamine	Inhibitor	/	Unkown
HY-146194	NHEJ inhibitor-1	Activator	/	Unkown
HY-149972	Antitumor agent-96	Inducer	/	Unkown
HY-158733	HR68		/	Unkown
HY-159091	HIV-1 integrase inhibitor 12	Inhibitor	/	Unkown
HY-162376	T3SS-IN-4	Inhibitor	/	Unkown
HY-163090	HR488B		/	Unkown
HY-168923	HR-568	Inhibitor	/	Unkown
HY-171159	MC-Val-Cit-PAB-Sunitinib		/	Unkown
HY-P10804	PIH	Inhibitor	/	Unkown
HY-P1807	Mast Cell Degranulating Peptide HR-2		/	Unkown
HY-P2717	Ac-YVAD-AMC	Inhibitor	/	Unkown
HY-P5398	HR2-18	Inhibitor	/	Unkown
HY-P5497	C34 peptide	Inhibitor	/	Unkown
HY-P5727	HR1	Inhibitor	/	Unkown
HY-RS06353	HR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124823	Monastroline	Inhibitor	/	Unkown
HY-157322	SAV13		/	Unkown
HY-170775	AChE-IN-83	Inhibitor	/	Unkown
HY-A0088S	Cefotaxime-d3 sodium	Inhibitor	/	Unkown
HY-W654305	Palbociclib-d4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hr	NCBI	NCBI:55806
Canis familiaris	Hr	NCBI	NCBI:486130
Macaca fascicularis	Hr	NCBI	NCBI:102146603
Canis lupus familiaris	Hr	NCBI
Mus musculus	Hr	NCBI	NCBI:15460
Susscrofa domestica	Hr	NCBI
Macaca mulatta	Hr	NCBI	NCBI:574164

Name
Email *

	Sorry, but the email address you supplied was invalid.