1. Gene
  2. Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

Mus musculus

Also known as Htt; Sert; 5-HTT

Gene ID: 15567 | Gene type: protein coding

About Slc6a4

Chromosome 11: 76,889,429-76,923,166 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 205 orthologues, 20 paralogues and is associated with 59 phenotypes. Broad expression in large intestine adult (RPKM 24.9), small intestine adult (RPKM 15.4) and 16 other tissues.

Summary

Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a4 Products(1)

mRNA Protein Name
NM_010484.2 NP_034614.2 sodium-dependent serotonin transporter
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables monoamine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
17452640 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17452640 MGI
enables serotonin:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
9037532 MGI
Biological Process GO Annotation Evidence Reference Source
involved in brain morphogenesis IMP
IMP: Inferred from mutant phenotype
19208814 MGI
involved in enteric nervous system development IMP
IMP: Inferred from mutant phenotype
27111230 MGI
involved in negative regulation of organ growth IMP
IMP: Inferred from mutant phenotype
19208814 MGI
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
9037532 MGI
involved in neurotransmitter reuptake IMP
IMP: Inferred from mutant phenotype
9037532 MGI
involved in neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
20858707 MGI
involved in platelet aggregation IMP
IMP: Inferred from mutant phenotype
18317590 MGI
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19308295 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19308295 MGI
involved in serotonin transport IMP
IMP: Inferred from mutant phenotype
19308295 MGI
involved in serotonin uptake IDA
IDA: Inferred from direct assay
17452640 MGI
involved in serotonin uptake IMP
IMP: Inferred from mutant phenotype
9547354 MGI
Cellular Component GO Annotation Evidence Reference Source
located in focal adhesion IDA
IDA: Inferred from direct assay
29038237 MGI
located in synapse IDA
IDA: Inferred from direct assay
29038237 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a4 Protein Structure

5HT_transport_N

5HT_transport_N: pfam03491 (23 - 63)

SLC6sbd_SERT

SLC6sbd_SERT: cd11513 (78 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 630 a.a.
Protein Preferred Names Protein Names

sodium-dependent serotonin transporter

5-hydroxytryptamine (serotonin) transporter

5HT transporter

5HTT

Sodium-dependent serotonin transporter (5HT transporter) (5HTT)

solute carrier family 6 member 4

Slc6a4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Slc6a4 Q60857 Nos1 Mus musculus Q9Z0J4 17452640
Intra
Slc6a4 Q60857 Nos1 Mus musculus Q9Z0J4 17452640
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a4 NCBI NCBI:6532