2. Gene
  3. Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Htt; Sert; 5-HTT

Gene ID: 15567 | Gene type: protein coding

About Slc6a4

Chromosome 11: 76,889,429-76,923,166 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 205 orthologues, 20 paralogues and is associated with 59 phenotypes. Broad expression in large intestine adult (RPKM 24.9), small intestine adult (RPKM 15.4) and 16 other tissues.

Summary

Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a4 Products(1)

mRNA Protein Name
NM_010484.2 NP_034614.2 sodium-dependent serotonin transporter

Slc6a4 Protein Structure

5HT_transport_N

5HT_transport_N: pfam03491 (23 - 63)

SLC6sbd_SERT

SLC6sbd_SERT: cd11513 (78 - 614)

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  • 630 a.a.
Protein Preferred Names Protein Names

sodium-dependent serotonin transporter

5-hydroxytryptamine (serotonin) transporter

5HT transporter

5HTT

Sodium-dependent serotonin transporter (5HT transporter) (5HTT)

solute carrier family 6 member 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110023 Zimelidine dihydrochloride Inhibitor 98.27% Unkown
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13313 Slc6a4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a4 NCBI NCBI:6532