PPTC7 - protein phosphatase targeting COQ7 Gene

Homo sapiens

Also known as TAPP2C; TA-PP2C

Gene ID: 160760 | Gene type: protein coding

About PPTC7

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,533,245-110,583,318 (from NCBI)

This gene has 2 transcripts (splice variants) and 278 orthologues. Ubiquitous expression in bone marrow (RPKM 18.8), heart (RPKM 15.4) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

PPTC7 Products(1)

mRNA	Protein	Name
NM_139283.2	NP_644812.1	protein phosphatase PTC7 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27499296	GOA
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	30267671	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-serine dephosphorylation	IMP IMP: Inferred from mutant phenotype	30267671	GOA
involved in regulation of ubiquinone biosynthetic process	IMP IMP: Inferred from mutant phenotype	30267671	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IMP IMP: Inferred from mutant phenotype	30267671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPTC7 Protein Structure

SpoIIE

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

protein phosphatase PTC7 homolog

PTC7 protein phosphatase homolog

PPTC7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPTC7	Q8NI37	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	PPTC7	Q8NI37	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	PPTC7	Q8NI37	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	PPTC7	Q8NI37	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	PPTC7	Q8NI37	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	PPTC7	Q8NI37	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	PPTC7	Q8NI37	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PPTC7	Q8NI37	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PPTC7	Q8NI37	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	PPTC7	Q8NI37	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PPTC7	Q8NI37	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PPTC7	Q8NI37	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PPTC7	Q8NI37	PBXIP1	Homo sapiens	Q96AQ6	Validated Y2H	32296183
Intra	PPTC7	Q8NI37	BNIP3	Homo sapiens	Q12983	Anti Tag CoIP	27499296

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11040	PPTC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PPTC7	VGNC	VGNC:44931
Felis catus	PPTC7	VGNC	VGNC:64336
Mus musculus	PPTC7	MGD	MGI:2444593
Bos taurus	PPTC7	VGNC	VGNC:33278
Rattus norvegicus	PPTC7	RGD	RGD:1310383

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