PBXIP1 - PBX homeobox interacting protein 1 Gene

Homo sapiens

Also known as HPIP

Gene ID: 57326 | Gene type: protein coding

About PBXIP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,944,080-154,956,099 (from NCBI)

This gene has 6 transcripts (splice variants) and 101 orthologues. Ubiquitous expression in ovary (RPKM 58.0), adrenal (RPKM 56.0) and 25 other tissues.

Summary

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast Cancer, brain tumors, and lung Cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

PBXIP1 Products(3)

mRNA	Protein	Name
NM_001317734.2	NP_001304663.1	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 2
NM_001317735.2	NP_001304664.1	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 3
NM_020524.4	NP_065385.2	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10825160	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	10825160	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hemopoiesis	IEP IEP: Inferred from expression pattern	10825160	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10825160	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	10825160	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10825160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor-interacting protein 1

hematopoietic PBX-interacting protein

PBXIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PBXIP1	Q96AQ6	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	PBXIP1	Q96AQ6	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	25416956
Intra	PBXIP1	Q96AQ6	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	PBXIP1	Q96AQ6	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	PBXIP1	Q96AQ6	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	PBXIP1	Q96AQ6	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Anti Tag CoIP	33961781
Intra	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Anti Tag CoIP	33961781
Intra	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Validated Y2H	25416956
Intra	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	25416956
Intra	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	31515488
Intra	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	19060904
Intra	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	19060904
Intra	PBXIP1	Q96AQ6	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	25416956
Intra	PBXIP1	Q96AQ6	DEF6	Homo sapiens	Q9H4E7	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Validated Y2H	25416956
Intra	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Y2H Array	25416956
Intra	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Y2H Prey Pooling	25416956
Intra	PBXIP1	Q96AQ6	LCA5L	Homo sapiens	O95447	Y2H Array	32296183
Intra	PBXIP1	Q96AQ6	LCA5L	Homo sapiens	O95447	Y2H Prey Pooling	32296183
Intra	PBXIP1	Q96AQ6	PPTC7	Homo sapiens	Q8NI37	Y2H Array	32296183
Intra	PBXIP1	Q96AQ6	PPTC7	Homo sapiens	Q8NI37	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10110	PBXIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PBXIP1	RGD	RGD:1305180
Bos taurus	PBXIP1	VGNC	VGNC:32611
Macaca mulatta	PBXIP1	VGNC	VGNC:75663
Felis catus	PBXIP1	VGNC	VGNC:103739
Mus musculus	PBXIP1	MGD	MGI:2441670
Canis familiaris	PBXIP1	VGNC	VGNC:44290

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