Ilk - integrin linked kinase Gene

Mus musculus

Also known as ILK-1; ILK-2; ESTM24; p59ILK

Gene ID: 16202 | Gene type: protein coding

About Ilk

Summary

Predicted to enable several functions, including SH3 domain binding activity; Integrin binding activity; and protein kinase binding activity. Involved in outflow tract morphogenesis; positive regulation of BMP signaling pathway; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including fibroblast migration; nervous system development; and protein kinase B signaling. Located in focal adhesion and lamellipodium. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ILK (Integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ilk Products(2)

mRNA	Protein	Name
NM_001161724.1	NP_001155196.1	integrin-linked protein kinase
NM_010562.2	NP_034692.2	integrin-linked protein kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10574708	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Schwann cell development	IMP IMP: Inferred from mutant phenotype	19349584	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	15831470	MGI
involved in caveola assembly	IMP IMP: Inferred from mutant phenotype	20951348	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12835312	MGI
acts upstream of or within cell projection organization	IMP IMP: Inferred from mutant phenotype	19349584	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	12670870	MGI
acts upstream of or within fibroblast migration	IMP IMP: Inferred from mutant phenotype	23658024	MGI
acts upstream of or within myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	19349584	MGI
acts upstream of or within negative regulation of neural precursor cell proliferation	IGI IGI: Inferred from genetic interaction	24719101	MGI
acts upstream of or within negative regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	24719101	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	19349584	MGI
acts upstream of neural precursor cell proliferation	IGI IGI: Inferred from genetic interaction	24719101	MGI
acts upstream of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	24719101	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	24131868	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	19349584	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19349584	MGI
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20675382	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12835312	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20675382	MGI
involved in protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	20951348	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	12432066	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	18325335	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase	beta-integrin-linked kinase
integrin binding protein kinase

Ilk Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ilk	O55222	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	12432066
Cross	Ilk	O55222	LIMS1	Homo sapiens	P48059	ELISA	10574708
Intra	Ilk	O55222	Parva	Mus musculus	Q9EPC1	Anti Bait CoIP	19798050
Intra	Ilk	O55222	Parva	Mus musculus	Q9EPC1	Pull Down	19829382
Intra	Ilk	O55222	Parva	Mus musculus	Q9EPC1	Anti Tag CoIP	23612611
Intra	Ilk	O55222	Parva	Mus musculus	Q9EPC1	Anti Tag CoIP	19829382
Intra	Ilk	O55222	Parvb	Mus musculus	Q9ES46	Anti Tag CoIP	23612611
Intra	Ilk	O55222	Parvb	Mus musculus	Q9ES46	Anti Tag CoIP	19829382
Intra	Ilk	O55222	Parvb	Mus musculus	Q9ES46	Anti Bait CoIP	19798050
Intra	Ilk	O55222	Stub1	Mus musculus	Q9WUD1	Anti Tag CoIP	23612611
Intra	Ilk	O55222	Stub1	Mus musculus	Q9WUD1	Fluorescence	23612611

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18676	OSU-T315		99.88%	Unkown
HY-113439	12-HETE	Inhibitor	95.70%	Unkown
HY-115677	ILK-IN-3	Inhibitor	99.62%	Unkown
HY-18676B	ILK-IN-2		99.41%	Unkown
HY-113439S	12-HETE-d8	Inhibitor	≥98.0%	Unkown
HY-RS06787	ILK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ilk	NCBI	NCBI:3611

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