RAMAC - RNA guanine-7 methyltransferase activating subunit Gene

Homo sapiens

Also known as RAM; RAMMET; C15orf18; FAM103A1; HsT19360

Gene ID: 83640 | Gene type: protein coding

About RAMAC

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,986,210-82,991,057 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues.

Summary

Enables RNA binding activity and Enzyme activator activity. Involved in methylation and recruitment of mRNA capping Enzyme to RNA polymerase II holoenzyme complex. Located in nucleoplasm. Part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

RAMAC Products(1)

mRNA	Protein	Name
NM_031452.4	NP_113640.1	RNA guanine-N7 methyltransferase activating subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	22099306	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	27422871	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	27422871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22099306	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 7-methylguanosine mRNA capping	IDA IDA: Inferred from direct assay	22099306	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mRNA cap methyltransferase RNMT:RAMAC complex	IDA IDA: Inferred from direct assay	22099306	GOA
part of mRNA capping enzyme complex	IDA IDA: Inferred from direct assay	27422871	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22099306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMAC Protein Structure

RAM

0
100
118 a.a.

Protein Preferred Names

Protein Names

RNA guanine-N7 methyltransferase activating subunit

RNMT activating mRNA cap methyltransferase subunit

RAMAC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAMAC	Q9BTL3	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	FOXI1	Homo sapiens	Q12951-2	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	FOXI1	Homo sapiens	Q12951-2	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	NAF1	Homo sapiens	Q96HR8	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	NAF1	Homo sapiens	Q96HR8	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	PRR3	Homo sapiens	P79522	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	PRR3	Homo sapiens	P79522	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	HNRNPH1	Homo sapiens	P31943	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	HNRNPH1	Homo sapiens	P31943	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	RAMAC	Q9BTL3	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	RAMAC	Q9BTL3	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	TEKT4	Homo sapiens	Q8WW24	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956
Intra	RAMAC	Q9BTL3	RBMY1F	Homo sapiens	Q15415	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	RBMY1F	Homo sapiens	Q15415	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	TEKT3	Homo sapiens	Q9BXF9	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	TEKT3	Homo sapiens	Q9BXF9	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	RNMT	Homo sapiens	O43148	Anti Tag CoIP	33961781
Intra	RAMAC	Q9BTL3	RNMT	Homo sapiens	O43148	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	RNMT	Homo sapiens	O43148	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	RAMAC	Q9BTL3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	RAMAC	Q9BTL3	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	RAMAC	Q9BTL3	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	32296183
Intra	RAMAC	Q9BTL3	TNS2	Homo sapiens	Q63HR2	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	RAMAC	Q9BTL3	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	RAMAC	Q9BTL3	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Murray Valley Encephalitis

Australian Encephalitis	Australian X Disease
Encephalitis Australia	Murray River Encephalitis
Australian Arboencephalitis	Australian X Disorder
Mve - [Murray Valley Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11637	RAMAC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAMAC	MGD	MGI:1914398
Rattus norvegicus	RAMAC	RGD	RGD:1310022
Bos taurus	RAMAC	VGNC	VGNC:55894
Canis familiaris	RAMAC	VGNC	VGNC:53171

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