1. Gene
  2. Ldlr - low density lipoprotein receptor Gene

Ldlr - low density lipoprotein receptor Gene

Mus musculus

Also known as Hlb301

Gene ID: 16835 | Gene type: protein coding

About Ldlr

Summary

Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ldlr Products(3)

mRNA Protein Name
NM_001252658.1 NP_001239587.1 low-density lipoprotein receptor isoform 2 precursor
NM_001252659.1 NP_001239588.1 low-density lipoprotein receptor isoform 3 presursor precursor
NM_010700.3 NP_034830.2 low-density lipoprotein receptor isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
22383525 MGI
enables low-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
7848292 MGI
enables low-density lipoprotein particle receptor activity IDA
IDA: Inferred from direct assay
12072432 MGI
enables low-density lipoprotein particle receptor activity IMP
IMP: Inferred from mutant phenotype
17148552 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12169628 MGI
enables very-low-density lipoprotein particle receptor activity IDA
IDA: Inferred from direct assay
16166565 MGI
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
20005821 MGI
involved in amyloid-beta clearance by cellular catabolic process IDA
IDA: Inferred from direct assay
22383525 MGI
involved in artery morphogenesis IMP
IMP: Inferred from mutant phenotype
22927332 MGI
involved in cellular response to fatty acid IGI
IGI: Inferred from genetic interaction
24255059 MGI
acts upstream of or within cholesterol homeostasis IGI
IGI: Inferred from genetic interaction
11120757 MGI
involved in cholesterol homeostasis IGI
IGI: Inferred from genetic interaction
25524771 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
9788969 MGI
involved in cholesterol import IMP
IMP: Inferred from mutant phenotype
18175806 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
17071966 MGI
acts upstream of or within cholesterol transport IMP
IMP: Inferred from mutant phenotype
17148552 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17148552 MGI
involved in high-density lipoprotein particle clearance IGI
IGI: Inferred from genetic interaction
25524771 MGI
acts upstream of or within lipid metabolic process IGI
IGI: Inferred from genetic interaction
11120757 MGI
acts upstream of or within lipoprotein catabolic process IDA
IDA: Inferred from direct assay
15741654 MGI
acts upstream of or within lipoprotein catabolic process IMP
IMP: Inferred from mutant phenotype
9788969 MGI
acts upstream of or within lipoprotein metabolic process IGI
IGI: Inferred from genetic interaction
11120757 MGI
involved in long-term memory IGI
IGI: Inferred from genetic interaction
24412220 MGI
acts upstream of or within low-density lipoprotein particle clearance IDA
IDA: Inferred from direct assay
26965651 MGI
involved in low-density lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in negative regulation of amyloid fibril formation IGI
IGI: Inferred from genetic interaction
20005821 MGI
involved in negative regulation of astrocyte activation IGI
IGI: Inferred from genetic interaction
20005821 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24255059 MGI
involved in negative regulation of microglial cell activation IGI
IGI: Inferred from genetic interaction
20005821 MGI
involved in negative regulation of protein metabolic process IDA
IDA: Inferred from direct assay
22383525 MGI
involved in phagocytosis IDA
IDA: Inferred from direct assay
22383525 MGI
involved in phospholipid transport IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in plasma lipoprotein particle clearance IDA
IDA: Inferred from direct assay
22383525 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
24255059 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24255059 MGI
involved in positive regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
24255059 MGI
involved in positive regulation of lysosomal protein catabolic process IDA
IDA: Inferred from direct assay
22383525 MGI
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
20005821 MGI
involved in regulation of cholesterol metabolic process IGI
IGI: Inferred from genetic interaction
24412220 MGI
involved in regulation of phosphatidylcholine catabolic process IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in regulation of protein metabolic process IGI
IGI: Inferred from genetic interaction
24412220 MGI
involved in response to caloric restriction IGI
IGI: Inferred from genetic interaction
24412220 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
22848640 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
22848640 MGI
located in cell surface IDA
IDA: Inferred from direct assay
22848640 MGI
located in early endosome IDA
IDA: Inferred from direct assay
11092755 MGI
located in endosome IDA
IDA: Inferred from direct assay
12746448 MGI
located in late endosome IDA
IDA: Inferred from direct assay
11092755 MGI
located in lysosome IDA
IDA: Inferred from direct assay
11092755 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20005821 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18341993 MGI
located in sorting endosome IDA
IDA: Inferred from direct assay
11092755 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor

LDL receptor

Recombinant Ldlr Proteins

Cat. No. Product Name Accession Purity
HY-P73272 LDLR Protein, Mouse (HEK293, His) P35951 (A22-R790) ≥95%
HY-P73838 LDLR Protein, Mouse (Biotinylated, A23V, C27G, HEK293, His) P35951/NP_034830.2 (A22-R790, A23V, C27G) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Ldlr NCBI NCBI:3949
Macaca fascicularis Ldlr NCBI NCBI:102127361