2. Gene
  3. COMMD6 - COMM domain containing 6 Gene

COMMD6 - COMM domain containing 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Acrg

Gene ID: 170622 | Gene type: protein coding

About COMMD6

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,525,214-75,549,439 (from NCBI)

This gene has 13 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 31.5), adrenal (RPKM 27.0) and 25 other tissues.

Summary

COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

COMMD6 Products(5)

mRNA Protein Name
NM_001287392.2 NP_001274321.1 COMM domain-containing protein 6 isoform c
NM_001287393.2 NP_001274322.1 COMM domain-containing protein 6 isoform c
NM_001287394.2 NP_001274323.1 COMM domain-containing protein 6 isoform c
NM_203495.4 NP_987091.1 COMM domain-containing protein 6 isoform b
NM_203497.4 NP_987093.1 COMM domain-containing protein 6 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
16573520 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16573520 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD6 Protein Structure

COMM_domain

COMM_domain: COMM domain (13 - 84)

  • 0
  • 85 a.a.
Protein Preferred Names Protein Names

COMM domain-containing protein 6

Acrg embryonic lethality minimal region ortholog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03013 COMMD6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus COMMD6 VGNC VGNC:61076
Mus musculus COMMD6 MGD MGI:1913450
Canis familiaris COMMD6 VGNC VGNC:54288
Rattus norvegicus COMMD6 RGD RGD:1560745
Macaca mulatta COMMD6 VGNC VGNC:103800