COMMD6 - COMM domain containing 6 Gene

Homo sapiens

Also known as Acrg

Gene ID: 170622 | Gene type: protein coding

About COMMD6

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,525,214-75,549,439 (from NCBI)

This gene has 13 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 31.5), adrenal (RPKM 27.0) and 25 other tissues.

Summary

COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

COMMD6 Products(5)

mRNA	Protein	Name
NM_001287392.2	NP_001274321.1	COMM domain-containing protein 6 isoform c
NM_001287393.2	NP_001274322.1	COMM domain-containing protein 6 isoform c
NM_001287394.2	NP_001274323.1	COMM domain-containing protein 6 isoform c
NM_203495.4	NP_987091.1	COMM domain-containing protein 6 isoform b
NM_203497.4	NP_987093.1	COMM domain-containing protein 6 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	16573520	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16573520	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD6 Protein Structure

COMM_domain

0
85 a.a.

Protein Preferred Names

Protein Names

COMM domain-containing protein 6

Acrg embryonic lethality minimal region ortholog

COMMD6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COMMD6	Q7Z4G1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	35271311
Intra	COMMD6	Q7Z4G1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	37172566
Intra	COMMD6	Q7Z4G1	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD6	Q7Z4G1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
Intra	COMMD6	Q7Z4G1	COMMD1	Homo sapiens	Q8N668	Validated Y2H	32296183
Intra	COMMD6	Q7Z4G1	COMMD1	Homo sapiens	Q8N668	Y2H Array	32296183
Intra	COMMD6	Q7Z4G1	COMMD1	Homo sapiens	Q8N668	Y2H Prey Pooling	25416956
Intra	COMMD6	Q7Z4G1	COMMD1	Homo sapiens	Q8N668	Y2H Prey Pooling	32296183
Intra	COMMD6	Q7Z4G1	COMMD1	Homo sapiens	Q8N668	Anti Bait CoIP	23563313
Intra	COMMD6	Q7Z4G1	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	35271311
Intra	COMMD6	Q7Z4G1	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	37172566
Intra	COMMD6	Q7Z4G1	COMMD9	Homo sapiens	Q9P000	Validated Y2H	32296183
Intra	COMMD6	Q7Z4G1	COMMD9	Homo sapiens	Q9P000	Anti Tag CoIP	33961781
Intra	COMMD6	Q7Z4G1	HSPA6	Homo sapiens	P17066	Y2H Array	32296183
Intra	COMMD6	Q7Z4G1	HSPA6	Homo sapiens	P17066	Y2H Prey Pooling	32296183
Intra	COMMD6	Q7Z4G1	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	37172566
Intra	COMMD6	Q7Z4G1	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	33961781
Intra	COMMD6	Q7Z4G1	CCDC22	Homo sapiens	O60826	Anti Bait CoIP	23563313
Intra	COMMD6	Q7Z4G1	CCDC22	Homo sapiens	O60826	Pull Down	23563313
Intra	COMMD6	Q7Z4G1	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03013	COMMD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	COMMD6	VGNC	VGNC:61076
Mus musculus	COMMD6	MGD	MGI:1913450
Canis familiaris	COMMD6	VGNC	VGNC:54288
Rattus norvegicus	COMMD6	RGD	RGD:1560745
Macaca mulatta	COMMD6	VGNC	VGNC:103800

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