2. Gene
  3. Kcnq2 - potassium voltage-gated channel subfamily Q member 2 Gene

Kcnq2 - potassium voltage-gated channel subfamily Q member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 170848 | Gene type: protein coding

About Kcnq2

Summary

Enables protein N-terminus binding activity and voltage-gated Potassium Channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq2 Products(1)

mRNA Protein Name
NM_133322.2 NP_579856.2 potassium voltage-gated channel subfamily KQT member 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12754513 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
11038262 RGD
Biological Process GO Annotation Evidence Reference Source
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
11038262 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon initial segment IDA
IDA: Inferred from direct assay
17311847 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11038262 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
11230508 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 2

KQT-like 2

potassium channel subunit alpha KvLQT2

potassium channel, voltage-gated KQT-like subfamily Q, member 2

potassium voltage-gated channel, KQT-like subfamily, member 2

voltage-gated potassium channel subunit Kv7.2

Kcnq2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Kcnq2 O88943 Calm1 Rattus norvegicus P0DP29
Anti Tag CoIP
22643219
Intra
Kcnq2 O88943 Calm1 Rattus norvegicus P0DP29
FRET
22643219
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108577 XE991 dihydrochloride Inhibitor 99.96% Unkown
HY-139791 Azetukalner Activator 99.77% Unkown
HY-122114 ICA-27243 Activator 99.18% Unkown
HY-101396 ICA-069673 Activator 99.65% Unkown
HY-145016 HN37 Activator 99.53% Unkown
HY-157485 Ebio1 Activator 99.99% Unkown
HY-113616A VU0364572 TFA Agonist 99.27% Unkown
HY-18063 ML252 Inhibitor 99.9% Unkown
HY-108587 ICA 110381 Modulator 99.85% Unkown
HY-123264 RL648_81 Inhibitor 99.20% Unkown
HY-108577A XE991 Inhibitor / Unkown
HY-113616 VU0364572 Agonist / Unkown
HY-130070 QO-40 Activator 98.77% Unkown
HY-168214 Kv7.2/Kv7.3 agonist 1 Inhibitor / Unkown
HY-172140 Ebio3 Inhibitor / Unkown
HY-172141 Ebio2 Activator / Unkown
HY-RS07174 KCNQ2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-115823 ztz240 / Unkown
HY-18063A ML252 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq2 NCBI NCBI:3785