Smad2 - SMAD family member 2 Gene

Mus musculus

Also known as Madh2; Madr2; mMad2; Smad-2; 7120426M23Rik

Gene ID: 17126 | Gene type: protein coding

About Smad2

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and Tau Protein binding activity. Involved in positive regulation of epithelial to mesenchymal transition and secondary palate development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 Products(3)

mRNA	Protein	Name
NM_001252481.1	NP_001239410.1	mothers against decapentaplegic homolog 2 isoform 1
NM_001311070.1	NP_001297999.1	mothers against decapentaplegic homolog 2 isoform 2
NM_010754.5	NP_034884.2	mothers against decapentaplegic homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	27336669	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IPI IPI: Inferred from physical interaction	24964035	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9702197	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11937490	MGI
enables SMAD binding	IPI IPI: Inferred from physical interaction	11160896	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15657445	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21724602	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9702197	MGI
enables tau protein binding	IDA IDA: Inferred from direct assay	24964035	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within SMAD protein signal transduction	IGI IGI: Inferred from genetic interaction	23390484	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9529255	MGI
involved in aortic valve morphogenesis	IGI IGI: Inferred from genetic interaction	23531444	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12842913	MGI
acts upstream of or within cell population proliferation	IGI IGI: Inferred from genetic interaction	19679673	MGI
acts upstream of or within developmental growth	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within embryonic foregut morphogenesis	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within embryonic pattern specification	IGI IGI: Inferred from genetic interaction	15183723	MGI
involved in endocardial cushion morphogenesis	IGI IGI: Inferred from genetic interaction	23531444	MGI
acts upstream of or within endoderm development	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within endoderm formation	IMP IMP: Inferred from mutant phenotype	21822279	MGI
acts upstream of or within gastrulation	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17849440	MGI
acts upstream of or within insulin secretion	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749725	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	15084457	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23152446	MGI
involved in odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	33548622	MGI
acts upstream of or within organ growth	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within pancreas development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within paraxial mesoderm morphogenesis	IMP IMP: Inferred from mutant phenotype	15084457	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within pericardium development	IGI IGI: Inferred from genetic interaction	15183723	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15282343	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14691138	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23152446	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9702197	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17159989	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	18990706	MGI
involved in pulmonary valve morphogenesis	IGI IGI: Inferred from genetic interaction	23531444	MGI
acts upstream of or within regulation of binding	IDA IDA: Inferred from direct assay	15282343	MGI
acts upstream of or within response to glucose	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within response to transforming growth factor beta	IGI IGI: Inferred from genetic interaction	19679673	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	11557747	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18212064	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	14656760	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14691138	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11160896	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9702197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 2

MAD homolog 2	Smad 2
mad-related protein 2	mothers against DPP homolog 2

Recombinant Smad2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73637	SMAD2 Protein, Mouse (sf9, His-GST)	Q62432 (S2-S467)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720	Luspatercept	Inhibitor	98.92%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N2037A	Higenamine hydrochloride		99.68%	Phase 1
HY-N2037	Higenamine		98.91%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99351	Andecaliximab	Inhibitor	95.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116084	Trimethylamine N-oxide	Activator	≥98.0%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	≥98.0%	Unkown
HY-116084S	Trimethylamine N-oxide-d9	Activator	≥99.0%	Unkown
HY-18766	EW-7195	Inhibitor	99.20%	Unkown
HY-123900	AZ12799734	Inhibitor	98.07%	Unkown
HY-100444	SIS3 free base	Inhibitor	98.11%	Unkown
HY-144043	ALK5-IN-8	Inhibitor	98.06%	Unkown
HY-118528A	TP0427736 hydrochloride	Inhibitor	99.22%	Unkown
HY-122856	AZ12601011	Inhibitor	99.88%	Unkown
HY-100448A	Butaprost		99.00%	Unkown
HY-N4107	Phyllanthin	Inhibitor	99.96%	Unkown
HY-P10414A	Klotho-derived peptide 1 hydrochloride	Inhibitor	97.28%	Unkown
HY-116084S1	Trimethylamine-N-oxide-13C3	Activator	/	Unkown
HY-161398	TGFβRII-IN-3		/	Unkown
HY-162404	Smad2/3-IN-2	Inhibitor	/	Unkown
HY-162405	Smad2/3-IN-1	Inhibitor	/	Unkown
HY-168607	ALK5-IN-83	Inhibitor	/	Unkown
HY-P10363	Tiger17	Activator	/	Unkown
HY-P10414	Klotho-derived peptide 1	Inhibitor	/	Unkown
HY-RS13393	SMAD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W108953	Myristoyl tetrapeptide-12	Activator	/	Unkown
HY-118528	TP0427736	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad2	NCBI	NCBI:4087

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