2. Stem Cell/Wnt MAPK/ERK Pathway TGF-beta/Smad
  3. Wnt MAP4K TGF-beta/Smad
  4. NCB-0970

NCB-0970 is the negative control of NCB-0846 (HY-100830). NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation.

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NCB-0970 Chemical Structure

NCB-0970 Chemical Structure

CAS No. : 2749881-54-5

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NCB-0970 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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Description

NCB-0970 is the negative control of NCB-0846 (HY-100830). NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation[1][2].

IC50 & Target

TNIK

21 nM (IC50)

Molecular Weight

375.42

Formula

C21H21N5O2
CAS No.
SMILES

O[C@H](CC1)CC[C@@H]1OC2=CC=CC3=C2N=C(NC4=CC=C(N=CN5)C5=C4)N=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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NCB-0970 Related Classifications

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Keywords:

NCB-09702749881-54-5NCB0970NCB 0970WntMAP4KTGF-beta/SmadMAPK Kinase Kinase KinaseTransforming growth factor betaInhibitorinhibitorinhibit

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