2. Gene
  3. Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nrf2

Gene ID: 18024 | Gene type: protein coding

About Nfe2l2

Chromosome 2: 75,505,857-75,534,985 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 92 phenotypes. Ubiquitous expression in bladder adult (RPKM 57.1), duodenum adult (RPKM 26.8) and 26 other tissues.

Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]

Nfe2l2 Products(2)

mRNA Protein Name
NM_001399226.1 NP_001386155.1 nuclear factor erythroid 2-related factor 2 isoform 2
NM_010902.5 NP_035032.1 nuclear factor erythroid 2-related factor 2 isoform 1

Nfe2l2 Protein Structure

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (485 - 552)

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (486 - 548)

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  • 597 a.a.
Protein Preferred Names Protein Names

nuclear factor erythroid 2-related factor 2

NF-E2-related factor 2

NFE2-related factor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12213 CDDO-EA Activator 99.71% Unkown
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-145390 Nrf2 activator-1 Activator / Unkown
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfe2l2 NCBI NCBI:4780