Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

Mus musculus

Also known as Nrf2

Gene ID: 18024 | Gene type: protein coding

About Nfe2l2

Chromosome 2: 75,505,857-75,534,985 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 92 phenotypes. Ubiquitous expression in bladder adult (RPKM 57.1), duodenum adult (RPKM 26.8) and 26 other tissues.

Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]

Nfe2l2 Products(2)

mRNA	Protein	Name
NM_001399226.1	NP_001386155.1	nuclear factor erythroid 2-related factor 2 isoform 2
NM_010902.5	NP_035032.1	nuclear factor erythroid 2-related factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12220541	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10037736	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9240432	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10037736	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9240432	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9240432	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9240432	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	17920186	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	14517290	MGI
involved in cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	14978030	MGI
acts upstream of or within cellular response to copper ion	IMP IMP: Inferred from mutant phenotype	24462598	MGI
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	14978030	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	9240432	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	20978266	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	24486487	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	14517290	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	24486487	MGI
involved in negative regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	23434824	MGI
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	24024172	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14517290	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	15087497	MGI
involved in positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	14978030	MGI
involved in positive regulation of glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	14978030	MGI
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10037736	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24462598	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14978030	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	24866179	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12220541	MGI
acts upstream of or within regulation of embryonic development	IGI IGI: Inferred from genetic interaction	15087497	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	16585964	MGI
involved in regulation of removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	14978030	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20978343	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14978030	MGI
located in cytoplasm	IPI IPI: Inferred from physical interaction	14517290	MGI
located in cytosol	IDA IDA: Inferred from direct assay	23043106	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14517290	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	14517290	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfe2l2 Protein Structure

bZIP_NFE2-like

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

nuclear factor erythroid 2-related factor 2

NF-E2-related factor 2

NFE2-related factor 2

Nfe2l2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nfe2l2	Q60795	Keap1	Mus musculus	Q9Z2X8	IF	38556546
Intra	Nfe2l2	Q60795	Keap1	Mus musculus	Q9Z2X8	Anti Bait CoIP	38556546
Intra	Nfe2l2	Q60795	Keap1	Mus musculus	Q9Z2X8	Pull Down	24366543

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12213	CDDO-EA	Activator	99.71%	Unkown
HY-145390	Nrf2 activator-1	Activator	98.66%	Unkown
HY-RS09245	NFE2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09246	Nfe2l2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09247	Nfe2l2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfe2l2	NCBI	NCBI:4780

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