2. Gene
  3. Pim1 - proviral integration site 1 Gene

Pim1 - proviral integration site 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pim-1

Gene ID: 18712 | Gene type: protein coding

About Pim1

Chromosome 17: 29,709,727-29,715,086 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in adrenal adult (RPKM 59.9), duodenum adult (RPKM 47.) and 24 other tissues.

Summary

Enables ATP binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of brown fat cell differentiation; protein stabilization; and regulation of hematopoietic stem cell proliferation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; primitive streak; and spleen. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim1 Products(2)

mRNA Protein Name
NM_008842.4 NP_032868.2 serine/threonine-protein kinase pim-1 isoform 1
NM_001364913.1 NP_001351842.1 serine/threonine-protein kinase pim-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
1825810 MGI
enables manganese ion binding IDA
IDA: Inferred from direct assay
1825810 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18438430 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1825810 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18438430 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
27923061 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
1825810 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
18438430 MGI
involved in regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
23495171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim1 Protein Structure

PKc_like

PKc_like: cl21453 (36 - 289)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-1

proto-oncogene serine/threonine-protein kinase pim-1

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
HY-19322 PIM447 Inhibitor 99.52% Phase 1
Pre-clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.40% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-16576A SMI-4a Inhibitor 99.63% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-101947 SMI-16a Inhibitor ≥98.0% Unkown
HY-135906 CK2/ERK8-IN-1 Inhibitor ≥99.0% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-18086 TCS PIM-1 1 Inhibitor 98.01% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-108605 PIM1-IN-2 Inhibitor ≥99.0% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-168071 Pim-1 kinase inhibitor 11 Inhibitor / Unkown
HY-123983 HS56 Inhibitor / Unkown
HY-149054 GSK-3β inhibitor 13 Inhibitor / Unkown
HY-147921 PIM1-IN-7 Inhibitor / Unkown
HY-135816 CK2/PIM1-IN-1 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-156470 Multi-kinase-IN-6 Inhibitor / Unkown
HY-150731 Pim-1 kinase inhibitor 3 Inhibitor / Unkown
HY-147920 PIM1-IN-6 Inhibitor / Unkown
HY-143897 PIM1-IN-3 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-168517 PIM-1/CK2-IN-2 Inhibitor / Unkown
HY-143898 PIM1-IN-4 Inhibitor / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim1 NCBI NCBI:5292