2. Gene
  3. Pim2 - proviral integration site 2 Gene

Pim2 - proviral integration site 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pim-2; DXCch3

Gene ID: 18715 | Gene type: protein coding

About Pim2

Chromosome X: 7,744,501-7,749,671 forward strand.GRCm39:CM001013.3

This gene has 3 transcripts (splice variants), 115 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen adult (RPKM 19.6), thymus adult (RPKM 12.7) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of autophagy; and protein stabilization. Acts upstream of or within several processes, including apoptotic mitochondrial changes; negative regulation of protein binding activity; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in spleen and thymus. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim2 Products(1)

mRNA Protein Name
NM_138606.2 NP_613072.1 serine/threonine-protein kinase pim-2

Pim2 Protein Structure

PKc_like

PKc_like: cl21453 (89 - 345)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-2

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-15604 AZD1208 Inhibitor 99.71% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
HY-19322 PIM447 Inhibitor 99.78% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.92% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-16576A SMI-4a Inhibitor 99.63% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-101947 SMI-16a Inhibitor ≥98.0% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-15698 CRT0066101 Inhibitor 95.11% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-164460 AZD1897 Inhibitor / Unkown
HY-101870 Uzansertib Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-123983 HS56 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-160006 PIM-IN-2 / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim2 NCBI NCBI:11040