Pim2 - proviral integration site 2 Gene

Mus musculus

Also known as Pim-2; DXCch3

Gene ID: 18715 | Gene type: protein coding

About Pim2

Chromosome X: 7,744,501-7,749,671 forward strand.GRCm39:CM001013.3

This gene has 3 transcripts (splice variants), 115 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen adult (RPKM 19.6), thymus adult (RPKM 12.7) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of autophagy; and protein stabilization. Acts upstream of or within several processes, including apoptotic mitochondrial changes; negative regulation of protein binding activity; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in spleen and thymus. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim2 Products(1)

mRNA	Protein	Name
NM_138606.2	NP_613072.1	serine/threonine-protein kinase pim-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11854514	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	11854514	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12869584	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	12869584	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17476689	MGI
acts upstream of macroautophagy	IMP IMP: Inferred from mutant phenotype	17476689	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12869584	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17476689	MGI
acts upstream of or within negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	17476689	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18438430	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	17476689	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15548703	MGI
acts upstream of or within positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	17476689	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15548703	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	18438430	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim2 Protein Structure

PKc_like

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase pim-2

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101870B	Uzansertib phosphate	Inhibitor	99.39%	Phase 2
HY-101870	Uzansertib	Inhibitor	99.45%	Phase 2
HY-15604	AZD1208	Inhibitor	99.71%	Phase 1
HY-19322B	PIM-447 dihydrochloride	Inhibitor	99.94%	Phase 1
HY-19322	PIM447	Inhibitor	99.52%	Phase 1
HY-15698	CRT0066101	Inhibitor	99.66%	Phase 1
HY-15604A	AZD1208 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15698A	CRT0066101 dihydrochloride	Inhibitor	99.92%	Unkown
HY-N4149	Quercetagetin	Inhibitor	99.94%	Unkown
HY-16576A	SMI-4a	Inhibitor	99.63%	Unkown
HY-16976	GDC-0339	Inhibitor	99.87%	Unkown
HY-101947	SMI-16a	Inhibitor	≥98.0%	Unkown
HY-120758	SEL24-B489	Inhibitor	99.02%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.83%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-164460	AZD1897	Inhibitor	99.69%	Unkown
HY-101783	GNE-955	Inhibitor	/	Unkown
HY-163119	Pim-1 kinase inhibitor 9	Inhibitor	/	Unkown
HY-123983	HS56	Inhibitor	/	Unkown
HY-168479	VB1080	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-163442A	PIM3-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-160006	PIM-IN-2		/	Unkown
HY-15698B	CRT0066101 trihydrochloride	Inhibitor	/	Unkown
HY-157404	Pim-1/2 kinase inhibitor 2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pim2	NCBI	NCBI:11040

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