Prkaca - protein kinase, cAMP dependent, catalytic, alpha Gene

Mus musculus

Also known as PKCD; Pkaca

Gene ID: 18747 | Gene type: protein coding

About Prkaca

Chromosome 8: 84,699,622-84,723,072 forward strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 288 orthologues, 4 paralogues and is associated with 10 phenotypes. Ubiquitous expression in heart adult (RPKM 86.7), subcutaneous fat pad adult (RPKM 59.9) and 28 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]

Prkaca Products(2)

mRNA	Protein	Name
NM_001277898.1	NP_001264827.1	cAMP-dependent protein kinase catalytic subunit alpha isoform 2
NM_008854.5	NP_032880.1	cAMP-dependent protein kinase catalytic subunit alpha isoform 1

Prkaca Protein Structure

STKc_PKA

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha

sperm cAMP-dependent protein kinase catalytic subunit

Prkaca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Prkaca	P05132	Pkia	Mus musculus	P63248	ITC	26833386
Intra	Prkaca	P05132	Pkia	Mus musculus	P63248	NMR	26833386
Intra	Prkaca	P05132	Prkar2b	Mus musculus	P31324	X-Ray Diffraction	22323819
Intra	Prkaca	P05132	Prkar2b	Mus musculus	P31324	GMS	22323819
Intra	Prkaca	P05132	Prkar2b	Mus musculus	P31324	Solid Phase Assay	21614075
Intra	Prkaca	P05132	Prkar2b	Mus musculus	P31324	SAXS	22323819
Intra	Prkaca	P05132	Prkar2b	Mus musculus	P31324	Anti Tag CoIP	21614075
Cross	Prkaca	P05132	PRKAR1A	Bos taurus	P00514	GMS	26278174
Cross	Prkaca	P05132	PRKAR1A	Bos taurus	P00514	X-Ray Diffraction	21300294
Cross	Prkaca	P05132	PRKAR1A	Bos taurus	P00514	SAXS	21300294
Cross	Prkaca	P05132	PRKAR1A	Bos taurus	P00514	X-Ray Diffraction	26278174
Cross	Prkaca	P05132	PRKAR1A	Bos taurus	P00514	GMS	21300294

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153967	BLU0588	Inhibitor	95.92%	Unkown
HY-150076	BLU2864	Inhibitor	99.24%	Unkown
HY-150072	DS89002333	Inhibitor	99.87%	Unkown
HY-150072B	(R)-DS89002333		98.74%	Unkown
HY-150072A	(2S,4R)-DS89002333		/	Unkown
HY-150073	DS01080522	Inhibitor	/	Unkown
HY-RS11104	PRKACA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11105	Prkaca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11106	Prkaca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaca	NCBI	NCBI:5566
Canis familiaris	Prkaca	NCBI	NCBI:403556

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