EEF1G - eukaryotic translation elongation factor 1 gamma Gene

Homo sapiens

Also known as EF1G; GIG35

Gene ID: 1937 | Gene type: protein coding

About EEF1G

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,559,596-62,573,891 (from NCBI)

This gene has 4 transcripts (splice variants), 235 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 1189.4), lymph node (RPKM 694.2) and 25 other tissues.

Summary

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

EEF1G Products(1)

mRNA	Protein	Name
NM_001404.5	NP_001395.1	elongation factor 1-gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10908348	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8743958	GOA
colocalizes with endoplasmic reticulum	IDA IDA: Inferred from direct assay	8743958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1G Protein Structure

GST_N

GST_C

EF1G

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

elongation factor 1-gamma

EF-1-gamma

EEF1G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EEF1G	P26641	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	EEF1G	P26641	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	EEF1G	P26641	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	EEF1G	P26641	EEF1B2	Homo sapiens	P24534	Anti Tag CoIP	33961781
Intra	EEF1G	P26641	EEF1B2	Homo sapiens	P24534	Anti Tag CoIP	28514442
Intra	EEF1G	P26641	EEF1B2	Homo sapiens	P24534	Anti Tag CoIP	35271311
Intra	EEF1G	P26641	EEF1B2	Homo sapiens	P24534	Y2H Pooling	16169070
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692	Anti Tag CoIP	35271311
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692	Crosslink	30021884
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692	Y2H Pooling	16169070
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692	Anti Tag CoIP	33961781
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	EEF1G	P26641	EEF1D	Homo sapiens	P29692-2	Anti Tag CoIP	28514442
Intra	EEF1G	P26641	TRIM63	Homo sapiens	Q969Q1	Y2H	18157088
Intra	EEF1G	P26641	TRIM63	Homo sapiens	Q969Q1	Pull Down	18157088

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontiac Fever

Podoconiosis

PDCOS	Podoconiosis, Susceptibility To
Nonfilarial Elephantiasis Of Lower Legs	Nonfilarial Elephantiasis Of Lower Legs, Susceptibility To
Endemic Nonfilarial Elephantiasis	Endemic Nonfilarial Elephantiasis, Susceptibility To
Lymphostatic Verrucosis	Lymphostatic Verrucosis, Susceptibility To
Elephantiasis	Endemic Non-Filarial Elephantiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04179	EEF1G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EEF1G	MGD	MGI:1914410
Rattus norvegicus	EEF1G	RGD	RGD:1302939
Bos taurus	EEF1G	VGNC	VGNC:28334
Felis catus	EEF1G	VGNC	VGNC:81197

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