EIF1AX - eukaryotic translation initiation factor 1A X-linked Gene

Homo sapiens

Also known as EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1

Gene ID: 1964 | Gene type: protein coding

About EIF1AX

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:20,124,525-20,141,838 (from NCBI)

This gene has 2 transcripts (splice variants), 254 orthologues, 1 paralogue and is associated with 69 phenotypes. Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

EIF1AX Products(1)

mRNA	Protein	Name
NM_001412.4	NP_001403.1	eukaryotic translation initiation factor 1A, X-chromosomal

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21139563	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosome assembly	IDA IDA: Inferred from direct assay	35732735	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	9732867	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic 43S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of eukaryotic 48S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of multi-eIF complex	IDA IDA: Inferred from direct assay	9732867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1AX Protein Structure

eIF-1a

0
100
144 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 1A, X-chromosomal

Putative eukaryotic translation initiation factor 1A

EIF1AX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF1AX	P47813	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF1AX	P47813	EIF3A	Homo sapiens	Q14152	Pull Down	23623729
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	X-Ray Diffraction	23435562
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	GMS	23435562
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	TSA	23435562

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1AX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70355	EIF1AX Protein, Human (His)	P47813 (M1-I144)	≥95%

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Choroid Cancer

Choroid Neoplasm	Choroidal Tumor
Malignant Tumor Of Choroid	Malignant Tumor Of The Choroid
Neoplasm Of Choroid	Choroid Neoplasms
Primary Malignant Neoplasm Of Choroid

Posterior Uveal Melanoma

Medium/Large Size Posterior Uveal Melanoma	Small Size Posterior Uveal Melanoma
Ciliary Body And Choroid Melanoma, Medium/Large Size	Ciliary Body And Choroid Melanoma, Small Size

Malignant Choroid Melanoma

Malignant Melanoma Of Choroid

Melanoma Of The Choroid

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Epithelioid Cell Melanoma

Epithelioid Melanoma

Malignant Conjunctival Melanoma

Conjunctival Melanoma	Malignant Melanoma Of Conjunctiva
Conjunctival Malignant Melanoma

Meningeal Melanoma

Melanoma Of The Leptomeninges

Leptomeningeal Melanoma

Malignant Leptomeningeal Tumor

Malignant Leptomeningeal Tumour	Malignant Tumor Of Leptomeninges
Malignant Tumour Of Leptomeninges	Malignant Leptomeningeal Neoplasm

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Conjunctival Cancer

Malignant Neoplasm Of Conjunctiva	Conjunctival Neoplasms
Conjunctival Tumor	Malignant Conjunctival Tumor
Malignant Tumor Of Conjunctiva	Neoplasm Of Conjunctiva
Conjunctiva Cancer	Primary Malignant Neoplasm Of Conjunctiva

Ovarian Endometrioid Adenofibroma

Meningeal Melanocytoma

Leptomeningeal Melanocytoma

Melanocytoma Of Meninges

Central Nervous System Melanocytic Neoplasm

Primary Melanocytic Lesion Of Meninges	Central Nervous System Primary Melanocytic Lesion
Melanocytic Tumor Of The Cns	Primary Melanocytic Lesions Of The Cns

Meningeal Melanomatosis

Leptomeningeal Melanomatosis

Uveal Disease

Uveal Diseases

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Diffuse Meningeal Melanocytosis

Diffuse Melanocytosis

Diffuse Melanosis

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma	Follicular Adenocarcinoma
Follicular Adenocarcinoma, Well Differentiated	Follicular Carcinoma
Thyroid Adenocarcinoma	Adenocarcinoma, Follicular

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

Multinodular Goiter

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04238	EIF1AX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EIF1AX	VGNC	VGNC:54830
Rattus norvegicus	EIF1AX	RGD	RGD:1560198
Bos taurus	EIF1AX	VGNC	VGNC:56706
Mus musculus	EIF1AX	MGD	MGI:1913485
Others	EIF1AX	NCBI

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