DCP1B - decapping mRNA 1B Gene

Homo sapiens

Also known as DCP1

Gene ID: 196513 | Gene type: protein coding

About DCP1B

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:1,941,591-2,004,457 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 212 orthologues and 1 paralogue. Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

DCP1B Products(2)

mRNA	Protein	Name
NM_001319292.2	NP_001306221.1	mRNA-decapping enzyme 1B isoform 2
NM_152640.5	NP_689853.3	mRNA-decapping enzyme 1B isoform 1

DCP1B Protein Structure

DCP1

0
100
200
300
400
500
617 a.a.

Protein Preferred Names

Protein Names

mRNA-decapping enzyme 1B

DCP1 decapping enzyme homolog B

DCP1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCP1B	Q8IZD4	NSMAF	Homo sapiens	Q92636	Y2H	26133670
Intra	DCP1B	Q8IZD4	BAG4	Homo sapiens	O95429	Lumier	25036637
Intra	DCP1B	Q8IZD4	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
Intra	DCP1B	Q8IZD4	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
Intra	DCP1B	Q8IZD4	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	25036637
Intra	DCP1B	Q8IZD4	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	16364915
Intra	DCP1B	Q8IZD4	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	16364915
Intra	DCP1B	Q8IZD4	EDC3	Homo sapiens	Q96F86	Y2H Array	29892012
Intra	DCP1B	Q8IZD4	EDC3	Homo sapiens	Q96F86	BN-PAGE	26184334
Intra	DCP1B	Q8IZD4	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	35271311
Intra	DCP1B	Q8IZD4	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3	EEC3
Eec Syndrome 3	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03585	DCP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DCP1B	VGNC	VGNC:39809
Rattus norvegicus	DCP1B	RGD	RGD:1562214
Macaca mulatta	DCP1B	VGNC	VGNC:71699
Felis catus	DCP1B	VGNC	VGNC:61373
Bos taurus	DCP1B	VGNC	VGNC:27920
Mus musculus	DCP1B	MGD	MGI:2442404

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