Rest - RE1-silencing transcription factor Gene

Mus musculus

Also known as NRSF; REST4; 2610008J04Rik

Gene ID: 19712 | Gene type: protein coding

About Rest

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including auditory receptor cell stereocilium organization; regulation of gene expression; and regulation of neuron differentiation. Acts upstream of or within hematopoietic progenitor cell differentiation; negative regulation of neurogenesis; and regulation of gene expression. Located in cytosol and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rest Products(1)

mRNA	Protein	Name
NM_011263.2	NP_035393.2	RE1-silencing transcription factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15240883	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17130167	MGI
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29024663	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17130167	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16684532	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	11039732	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10490617	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10490617	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15907476	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	29961578	MGI
involved in cardiac muscle cell myoblast differentiation	IDA IDA: Inferred from direct assay	21199191	MGI
acts upstream of or within cellular response to stress	IDA IDA: Inferred from direct assay	29024663	MGI
involved in detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	29961578	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15240883	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17130167	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21884984	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	10490617	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9771705	MGI
acts upstream of or within negative regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	17403776	MGI
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	15907476	MGI
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	27819263	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	29961578	MGI
involved in neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	27819263	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	10490617	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29961578	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	21884984	MGI
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	21884984	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	29024663	MGI
involved in regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	25838543	MGI
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	27819263	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21199191	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10490617	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	17130167	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RE1-silencing transcription factor

neural-restrictive silencer factor

Rest Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rest	Q8VIG1	Prickle1	Mus musculus	Q3U5C7	Anti Bait CoIP	34597683

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0069	Fludarabine		99.91%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-70057	Safinamide	Inhibitor	99.89%	Yes
HY-70057A	Safinamide mesylate	Inhibitor	99.87%	Yes
HY-A0083B	Methacholine bromide	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12680	PRN694	Inhibitor	≥99.0%	Unkown
HY-136833	X5050	Inhibitor	98.01%	Unkown
HY-136460	Calcium ionophore I		≥99.0%	Unkown
HY-W013712	GI-530159	Activator	99.27%	Unkown
HY-106667	DL 071IT	Inhibitor	98.81%	Unkown
HY-RS11853	REST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-103178	MRE3008F20	Antagonist	99.70%	Unkown
HY-142682	SCP1-IN-1		98.63%	Unkown
HY-103298	MNI-caged kainate		/	Unkown
HY-116790B	(±)-Penbutolol	Antagonist	/	Unkown
HY-125452	DiSBAC10		/	Unkown
HY-137618B	Rp-dGTPαS		/	Unkown
HY-142683	SCP1-IN-2	Inhibitor	/	Unkown
HY-149483	CVN417	Antagonist	/	Unkown
HY-159986	X-17	Inhibitor	/	Unkown
HY-161272	Nav1.8-IN-6	Inhibitor	/	Unkown
HY-162478	GR-28		/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-N3313	Masticadienolic acid	Inhibitor	/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-118317	Zacopride		/	Unkown
HY-152901	Chol-N3		/	Unkown
HY-W328882	3-(2-Aminopropyl)phenol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rest	NCBI	NCBI:5978
Macaca fascicularis	Rest	NCBI	NCBI:102116020

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