REST - RE1 silencing transcription factor Gene

Homo sapiens

Also known as WT6; XBR; HGF5; NRSF; DFNA27; GINGF5

Gene ID: 5978 | Gene type: protein coding

About REST

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,907,900-56,935,844 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues, 29 paralogues and is associated with 5 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.2), testis (RPKM 8.5) and 25 other tissues.

Summary

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

REST Products(3)

mRNA	Protein	Name
NM_001193508.1	NP_001180437.1	RE1-silencing transcription factor
NM_001363453.2	NP_001350382.1	RE1-silencing transcription factor
NM_005612.5	NP_005603.3	RE1-silencing transcription factor

REST Protein Structure

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
1000
1097 a.a.

Protein Preferred Names

Protein Names

RE1-silencing transcription factor

neural-restrictive silencer factor

Related Diseases

Diseases

Alias

Fibromatosis, Gingival, 5

GINGF5	Ggf5
Fibromatosis, Gingival, Hereditary, 5	Hgf5
Gingival Fibromatosis 5

Wilms Tumor 6

WT6	Wilms Tumor 6, Susceptibility To
Susceptibility To Wilms Tumor 6	Wilms Tumor, Susceptibility To
Nephroblastoma

Deafness, Autosomal Dominant 27

DFNA27	Autosomal Dominant Nonsyndromic Deafness 27
Autosomal Dominant Deafness 27	Deafness, Autosomal Dominant, 27

Gingival Fibromatosis

Hereditary Gingival Fibromatosis	Hereditary Gingival Hyperplasia
Autosomal Dominant Gingival Fibromatosis	Autosomal Dominant Gingival Hyperplasia
Fibromatosis, Gingival, Hereditary	Fibromatosis, Gingival

Fibromatosis, Gingival, 1

GINGF1	Ggf1
Fibromatosis, Gingival, Hereditary	Hgf
Hereditary Gingival Fibromatosis	Gingf
Gingival Fibromatosis, 1	Fibromatosis Gingival, Hereditary, 1
Hgf1	Hereditary Gingival Fibromatosis, 1

Wilms Tumor Predisposition

Aging

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Fibromatosis

Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Ischemia

Acute Coronary Syndrome

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0069	Fludarabine		99.91%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-70057	Safinamide	Inhibitor	99.89%	Yes
HY-70057A	Safinamide mesylate	Inhibitor	99.87%	Yes
HY-A0083B	Methacholine bromide	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12680	PRN694	Inhibitor	≥99.0%	Unkown
HY-136833	X5050	Inhibitor	98.01%	Unkown
HY-136460	Calcium ionophore I		≥99.0%	Unkown
HY-W013712	GI-530159	Activator	99.27%	Unkown
HY-106667	DL 071IT	Inhibitor	/	Unkown
HY-RS11853	REST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-103178	MRE3008F20	Antagonist	99.70%	Unkown
HY-142682	SCP1-IN-1		98.63%	Unkown
HY-125452	DiSBAC10		/	Unkown
HY-137618B	Rp-dGTPαS		/	Unkown
HY-142683	SCP1-IN-2		/	Unkown
HY-149483	CVN417	Antagonist	/	Unkown
HY-161272	Nav1.8-IN-6	Inhibitor	/	Unkown
HY-162478	GR-28	Inhibitor	/	Unkown
HY-70057S1	Safinamide-d4-1	Inhibitor	/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-N3313	Masticadienolic acid	Inhibitor	/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-103298	MNI-caged kainate		/	Unkown
HY-118317	Zacopride		/	Unkown
HY-152901	Chol-N3		/	Unkown
HY-W328882	3-(2-Aminopropyl)phenol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	REST	MGD	MGI:104897
Rattus norvegicus	REST	RGD	RGD:621069
Macaca mulatta	REST	VGNC	VGNC:76898
Canis familiaris	REST	VGNC	VGNC:45480
Macaca fascicularis	REST	NCBI	NCBI:102116020
Others	REST	NCBI

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