EIF4B - eukaryotic translation initiation factor 4B Gene

Homo sapiens

Also known as EIF-4B; PRO1843

Gene ID: 1975 | Gene type: protein coding

About EIF4B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,006,456-53,042,215 (from NCBI)

This gene has 14 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022]

EIF4B Products(3)

mRNA	Protein	Name
NM_001300821.3	NP_001287750.1	eukaryotic translation initiation factor 4B isoform 1
NM_001330654.2	NP_001317583.1	eukaryotic translation initiation factor 4B isoform 3
NM_001417.7	NP_001408.2	eukaryotic translation initiation factor 4B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4B Protein Structure

RRM_1

0
100
200
300
400
500
611 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4B

EIF4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	EIF4B	P23588	PLK1	Homo sapiens	P53350	Protein Kinase Assay	21887822
Intra	EIF4B	P23588	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mouth Disease

Mouth Diseases

Mouth Disorders

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-129239	Farudodstat		99.68%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04273	EIF4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4B	RGD	RGD:1306479
Mus musculus	EIF4B	MGD	MGI:95304
Canis familiaris	EIF4B	VGNC	VGNC:40282
Bos taurus	EIF4B	VGNC	VGNC:28407
Felis catus	EIF4B	VGNC	VGNC:61790

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