ELK1 - ETS transcription factor ELK1 Gene

Homo sapiens

Gene ID: 2002 | Gene type: protein coding

About ELK1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,635,520-47,650,604 (from NCBI)

This gene has 4 transcripts (splice variants), 179 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 19.1), brain (RPKM 15.9) and 25 other tissues.

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

ELK1 Products(3)

mRNA	Protein	Name
NM_001114123.3	NP_001107595.1	ETS domain-containing protein Elk-1 isoform a
NM_001257168.1	NP_001244097.1	ETS domain-containing protein Elk-1 isoform b
NM_005229.4	NP_005220.2	ETS domain-containing protein Elk-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12750007	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14970218	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10799319	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12750007	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	26612202	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	31146003	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16291755	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	31146003	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15790681	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17296730	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	31146003	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12750007	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22065586	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20018936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK1 Protein Structure

Ets

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

ETS domain-containing protein Elk-1

ELK1, ETS transcription factor

Related Diseases

Diseases

Alias

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152860	Darizmetinib		99.94%	Unkown
HY-135699	TD52		≥95.0%	Unkown
HY-113592	ERK-IN-4	Inhibitor	99.61%	Unkown
HY-135699A	TD52 dihydrochloride		99.90%	Unkown
HY-RS04305	ELK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163323	AKR1C3-IN-12	Inhibitor	/	Unkown
HY-111000	BNC-1		/	Unkown
HY-122241	MT477	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ELK1	MGD	MGI:101833
Canis familiaris	ELK1	VGNC	VGNC:40303
Felis catus	ELK1	VGNC	VGNC:61810
Rattus norvegicus	ELK1	RGD	RGD:1598663
Bos taurus	ELK1	VGNC	VGNC:28432

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