APOBEC3F - apolipoprotein B mRNA editing enzyme catalytic subunit 3F Gene

Homo sapiens

Also known as A3F; KA6; ARP8; BK150C2.4.MRNA

Gene ID: 200316 | Gene type: protein coding

About APOBEC3F

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,040,864-39,055,972 (from NCBI)

This gene has 4 transcripts (splice variants), 52 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 2.8), ovary (RPKM 2.8) and 24 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

APOBEC3F Products(2)

mRNA	Protein	Name
NM_001006666.2	NP_001006667.1	DNA dC->dU-editing enzyme APOBEC-3F isoform b
NM_145298.6	NP_660341.2	DNA dC->dU-editing enzyme APOBEC-3F isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11863358	GOA
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	17121840	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23685212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16699599	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11863358	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	21835787	GOA
involved in base conversion or substitution editing	IDA IDA: Inferred from direct assay	17121840	GOA
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21835787	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	16378963	GOA
involved in negative regulation of viral process	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	21496894	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	16699599	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16527742	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16699599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3F Protein Structure

APOBEC_N

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3F

apolipoprotein B editing enzyme catalytic polypeptide-like 3F

APOBEC3F Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOBEC3F	Q8IUX4	APOBEC3F	Homo sapiens	Q8IUX4	X-Ray Diffraction	23685212
Intra	APOBEC3F	Q8IUX4	APOBEC3F	Homo sapiens	Q8IUX4	DLS	23685212
Intra	APOBEC3F	Q8IUX4	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	APOBEC3F	Q8IUX4	APOBEC3G	Homo sapiens	Q9HC16	Anti Tag CoIP	15152192

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00839	APOBEC3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120157	Vif-ElonginC interaction inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3F	MGD	MGI:1933111

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