APOBEC3G - apolipoprotein B mRNA editing enzyme catalytic subunit 3G Gene

Homo sapiens

Also known as A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1

Gene ID: 60489 | Gene type: protein coding

About APOBEC3G

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,077,005-39,087,743 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 19.7), spleen (RPKM 13.4) and 22 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]

APOBEC3G Products(4)

mRNA	Protein	Name
NM_001349436.1	NP_001336365.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 2
NM_001349437.2	NP_001336366.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 3
NM_001349438.3	NP_001336367.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 4
NM_021822.4	NP_068594.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11863358	GOA
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	12808465	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11863358	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14528301	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11863358	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	16571802	GOA
involved in cytidine deamination	IDA IDA: Inferred from direct assay	16378963	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	12808465	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	16571802	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	16378963	GOA
involved in negative regulation of viral process	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	17121840	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	16699599	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16527742	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16699599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3G Protein Structure

APOBEC_N

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3G

APOBEC-related cytidine deaminase

APOBEC3G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	Q77YG0	Pull Down	19887642
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	Q77YG0	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	PRKACA	Homo sapiens	P17612	Protein Kinase Assay	18836454
Intra	APOBEC3G	Q9HC16	APOBEC3G	Homo sapiens	Q9HC16	X-Ray Diffraction	20152150
Intra	APOBEC3G	Q9HC16	APOBEC3G	Homo sapiens	Q9HC16	Anti Tag CoIP	15152192
Intra	APOBEC3G	Q9HC16	N	Human SARS coronavirus	P59595	Pull Down	19345973
Intra	APOBEC3G	Q9HC16	CEBPB	Homo sapiens	P17676	Anti Tag CoIP	18809921
Intra	APOBEC3G	Q9HC16	N	Human coronavirus 229E	P15130	Pull Down	19345973
Intra	APOBEC3G	Q9HC16	ubiq_human	Homo sapiens	DIP-24261N	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P69723	Anti Tag CoIP	14528301
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P69723	Anti Tag CoIP	15152192
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P12504	Anti Tag CoIP	12859895
Intra	APOBEC3G	Q9HC16	C	Hepatitis B virus	Q784Z8	FRET	24557838

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W279260	APOBEC3G-IN-1	Inhibitor	96.54%	Unkown
HY-122156	IMB-301	Inhibitor	99.08%	Unkown
HY-148042	HIV-1 inhibitor-47	Inhibitor	≥98.0%	Unkown
HY-148138	Deaminase inhibitor-1	Inhibitor	99.64%	Unkown
HY-RS00840	APOBEC3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124870	N.41	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3G	MGD	MGI:1933111

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