EPB41L2 - erythrocyte membrane protein band 4.1 like 2 Gene

Homo sapiens

Also known as 4.1G; 4.1-G

Gene ID: 2037 | Gene type: protein coding

About EPB41L2

Cytogenetic location: 6q23.1-q23.2 Genomic coordinates (GRCh38): 6:130,839,347-131,063,245 (from NCBI)

This gene has 34 transcripts (splice variants), 230 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 33.9), ovary (RPKM 23.5) and 23 other tissues.

Summary

Predicted to enable PH domain binding activity; cytoskeletal protein binding activity; and structural molecule activity. Involved in positive regulation of protein localization to cell cortex. Located in cell junction; nucleoplasm; and plasma membrane. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

EPB41L2 Products(22)

mRNA	Protein	Name
NM_001135554.2	NP_001129026.1	band 4.1-like protein 2 isoform b
NM_001135555.4	NP_001129027.1	band 4.1-like protein 2 isoform b
NM_001199388.3	NP_001186317.1	band 4.1-like protein 2 isoform c
NM_001252660.2	NP_001239589.1	band 4.1-like protein 2 isoform d
NM_001350299.2	NP_001337228.1	band 4.1-like protein 2 isoform e
NM_001350301.2	NP_001337230.1	band 4.1-like protein 2 isoform f
NM_001350302.2	NP_001337231.1	band 4.1-like protein 2 isoform a
NM_001350303.2	NP_001337232.1	band 4.1-like protein 2 isoform g
NM_001350304.2	NP_001337233.1	band 4.1-like protein 2 isoform h
NM_001350305.2	NP_001337234.1	band 4.1-like protein 2 isoform h
NM_001350306.2	NP_001337235.1	band 4.1-like protein 2 isoform h
NM_001350307.2	NP_001337236.1	band 4.1-like protein 2 isoform i
NM_001350308.2	NP_001337237.1	band 4.1-like protein 2 isoform c
NM_001350309.1	NP_001337238.1	band 4.1-like protein 2 isoform c
NM_001350310.2	NP_001337239.1	band 4.1-like protein 2 isoform c
NM_001350311.2	NP_001337240.1	band 4.1-like protein 2 isoform d
NM_001350312.2	NP_001337241.1	band 4.1-like protein 2 isoform d
NM_001350313.2	NP_001337242.1	band 4.1-like protein 2 isoform d
NM_001350314.2	NP_001337243.1	band 4.1-like protein 2 isoform j
NM_001350315.2	NP_001337244.1	band 4.1-like protein 2 isoform j
NM_001350320.2	NP_001337249.1	band 4.1-like protein 2 isoform k
NM_001431.4	NP_001422.1	band 4.1-like protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	23870127	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	23870127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPB41L2 Protein Structure

FERM_N

FERM_M

FERM_C

SAB

4_1_CTD

0
200
400
600
800
1005 a.a.

Protein Preferred Names

Protein Names

band 4.1-like protein 2

erythrocyte membrane protein band 4.1 like-protein 2

EPB41L2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EPB41L2	O43491	FCGR1A	Homo sapiens	P12314	Anti Bait CoIP	22003208
Intra	EPB41L2	O43491	FCGR1A	Homo sapiens	P12314	Pull Down	22003208
Intra	EPB41L2	O43491	FCGR1A	Homo sapiens	P12314	IF	22003208
Intra	EPB41L2	O43491	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	EPB41L2	O43491	YWHAG	Homo sapiens	P61981	Y2H Pooling	20936779
Intra	EPB41L2	O43491	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	EPB41L2	O43491	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Cellular Congenital Mesoblastic Nephroma

Tuberculum Sellae Meningioma

Meningioma Of The Tuberculum Sellae

Sella Turcica Neoplasm

Tumor Of Sella Turcica

Cerebellopontine Angle Meningioma

Meningioma Of The Cerebellar Pontine Angle

Hereditary Elliptocytosis

Congenital Elliptocytosis	Ovalocytosis
Elliptocytosis, Hereditary	He
Elliptocytosis Hereditary	Congenital Ovalocytosis
Elliptocytosis	Hereditary Elliptocytosis With Infantile Poikilocytosis
Hereditary Ovalocytosis	Oval Erythrocytosis
He - [Hereditary Elliptocytosis]	Elliptocytosis Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04412	EPB41L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPB41L2	RGD	RGD:1563977
Mus musculus	EPB41L2	MGD	MGI:103009
Macaca mulatta	EPB41L2	VGNC	VGNC:72232
Bos taurus	EPB41L2	VGNC	VGNC:28521
Felis catus	EPB41L2	VGNC	VGNC:61893
Canis familiaris	EPB41L2	VGNC	VGNC:40394

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