Sp1 - trans-acting transcription factor 1 Gene

Mus musculus

Also known as Sp1-1; 1110003E12Rik

Gene ID: 20683 | Gene type: protein coding

About Sp1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and response to hydroperoxide. Acts upstream of or within several processes, including animal organ development; embryo development; and mRNA transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; epithelium; eye; and genitourinary system. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp1 Products(1)

mRNA	Protein	Name
NM_013672.2	NP_038700.2	transcription factor Sp1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9738004	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19943855	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1524678	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12119294	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22331133	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8617793	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12657651	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	12657651	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9705320	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
contributes to protein binding	IPI IPI: Inferred from physical interaction	10215616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	1909605	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11071760	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within definitive hemopoiesis	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within embryonic placenta development	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within embryonic process involved in female pregnancy	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within enucleate erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within liver development	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22331133	MGI
acts upstream of or within megakaryocyte differentiation	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within myeloid progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within ossification	IGI IGI: Inferred from genetic interaction	17584888	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15282343	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24030830	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1524678	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701757	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15663180	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21029371	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12119294	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27918959	MGI
involved in response to hydroperoxide	IDA IDA: Inferred from direct assay	27918959	MGI
acts upstream of or within trophectodermal cell differentiation	IGI IGI: Inferred from genetic interaction	17584888	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	21029371	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9705320	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor Sp1

specificity protein 1

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0122	Plicamycin	Inhibitor	99.60%	Unkown
HY-100008	Peretinoin		99.79%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10447	Terameprocol		99.33%	Phase 2
HY-N0842	Bevirimat	Inhibitor	99.82%	Phase 2
HY-P10603	SP1	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-20897A	5-Bromo-L-tryptophan		99.60%	Unkown
HY-W100287	Murrayafoline A	Inhibitor	99.73%	Unkown
HY-W353469	2-O-(α-D-Glucopyranosyl)glycerol (55% in water)		99.80%	Unkown
HY-N7078	Spiculisporic acid		≥98.0%	Unkown
HY-W006646	Methyl 5-bromo-1H-pyrrole-2-carboxylate		/	Unkown
HY-RS13600	SP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125538	Deoxybrevianamide E		99.2%	Unkown
HY-W010062	4-Chlorophenylacetic acid		99.93%	Unkown
HY-114585A	Sperabillin A dihydrochloride	Inhibitor	/	Unkown
HY-116077	AB 5046B		/	Unkown
HY-120764	PF-46396	Inhibitor	/	Unkown
HY-125458	Iromycin A	Inhibitor	/	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-N12266	12-Hydroxyalbrassitriol		/	Unkown
HY-N6799	Neosolaniol		99.72%	Unkown
HY-N8662	Primulic acid II		/	Unkown
HY-P1330	Purotoxin 1	Inhibitor	/	Unkown
HY-P3805	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Antagonist	/	Unkown
HY-108993	Fujianmycin B		/	Unkown
HY-120551	Fructigenine A		/	Unkown
HY-123036	Renierone	Inhibitor	/	Unkown
HY-N0980	1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid		/	Unkown
HY-N12149	Axinysone B	Inhibitor	/	Unkown
HY-N13017	Bhimanone		/	Unkown
HY-N13149	Tetromycin C1	Inhibitor	/	Unkown
HY-N14206	Cytosporin B		/	Unkown
HY-N14721	Erabulenol A	Inhibitor	/	Unkown
HY-N2657	Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate		/	Unkown
HY-N8339	Decatromicin B	Inhibitor	/	Unkown
HY-N8391	Hydroxysulochrin		/	Unkown
HY-N8849	4-Methyl-6,7-methylenedioxycoumarin	Inhibitor	/	Unkown
HY-P10336	Serpinin	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sp1	NCBI	NCBI:6667
Macaca fascicularis	Sp1	NCBI	NCBI:102115996
Rattus norvegicus	Sp1	NCBI	NCBI:24790
Macaca mulatta	Sp1	NCBI	NCBI:702710

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