2. Gene
  3. Sp1 - Sp1 transcription factor Gene

Sp1 - Sp1 transcription factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24790 | Gene type: protein coding

About Sp1

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; Histone Acetyltransferase binding activity; and transcription coregulator binding activity. Involved in cellular response to Insulin stimulus and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Part of protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp1 Products(1)

mRNA Protein Name
NM_012655.2 NP_036787.2 transcription factor Sp1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26908121 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
10362258 RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14979875 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
10837920 RGD
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
19765194 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10393239 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10837920 RGD
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
10362258 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
26908121 RGD
involved in cellular response to wortmannin IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
26908121 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11457835 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
26908121 RGD
located in nucleus IDA
IDA: Inferred from direct assay
14979875 RGD
part of protein-DNA complex IDA
IDA: Inferred from direct assay
19765194 RGD
part of protein-DNA complex IPI
IPI: Inferred from physical interaction
10362258 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp1

trans-acting transcription factor 1

Sp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sp1 Q01714 Nfya Rattus norvegicus P18576
Anti Bait CoIP
10393239
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0122 Plicamycin Inhibitor 99.60% Unkown
HY-100008 Peretinoin 99.79% Yes
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10447 Terameprocol 99.33% Phase 2
HY-N0842 Bevirimat Inhibitor 99.82% Phase 2
HY-P10603 SP1 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W040129 Chromomycin A3 99.66% Unkown
HY-20897A 5-Bromo-L-tryptophan 99.60% Unkown
HY-W100287 Murrayafoline A Inhibitor 99.73% Unkown
HY-W353469 2-O-(α-D-Glucopyranosyl)glycerol (55% in water) 99.80% Unkown
HY-N7078 Spiculisporic acid ≥98.0% Unkown
HY-W006646 Methyl 5-bromo-1H-pyrrole-2-carboxylate / Unkown
HY-RS13600 SP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-125538 Deoxybrevianamide E 99.2% Unkown
HY-W010062 4-Chlorophenylacetic acid 99.93% Unkown
HY-114585A Sperabillin A dihydrochloride Inhibitor / Unkown
HY-116077 AB 5046B / Unkown
HY-120764 PF-46396 Inhibitor / Unkown
HY-125458 Iromycin A Inhibitor / Unkown
HY-150536 EP39 Inhibitor / Unkown
HY-N12266 12-Hydroxyalbrassitriol / Unkown
HY-N6799 Neosolaniol 99.72% Unkown
HY-N8662 Primulic acid II / Unkown
HY-P1330 Purotoxin 1 Inhibitor / Unkown
HY-P3805 [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) Antagonist / Unkown
HY-108993 Fujianmycin B / Unkown
HY-120551 Fructigenine A / Unkown
HY-123036 Renierone Inhibitor / Unkown
HY-N0980 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid / Unkown
HY-N12149 Axinysone B Inhibitor / Unkown
HY-N13017 Bhimanone / Unkown
HY-N13149 Tetromycin C1 Inhibitor / Unkown
HY-N14206 Cytosporin B / Unkown
HY-N14721 Erabulenol A Inhibitor / Unkown
HY-N2657 Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate / Unkown
HY-N8339 Decatromicin B Inhibitor / Unkown
HY-N8391 Hydroxysulochrin / Unkown
HY-N8849 4-Methyl-6,7-methylenedioxycoumarin Inhibitor / Unkown
HY-P10336 Serpinin Agonist / Unkown
HY-RS16562 Sp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp1 NCBI NCBI:6667
Macaca fascicularis Sp1 NCBI NCBI:102115996
Mus musculus Sp1 NCBI NCBI:20683
Macaca mulatta Sp1 NCBI NCBI:702710