1. Gene
  2. Sp1 - Sp1 transcription factor Gene

Sp1 - Sp1 transcription factor Gene

Rattus norvegicus
Gene ID: 24790 | Gene type: protein coding

About Sp1

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; Histone Acetyltransferase binding activity; and transcription coregulator binding activity. Involved in cellular response to Insulin stimulus and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Part of protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp1 Products(1)

mRNA Protein Name
NM_012655.2 NP_036787.2 transcription factor Sp1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26908121 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
10362258 RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14979875 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
10837920 RGD
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
19765194 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10393239 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10837920 RGD
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
10362258 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
26908121 RGD
involved in cellular response to wortmannin IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
26908121 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11457835 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
26908121 RGD
located in nucleus IDA
IDA: Inferred from direct assay
14979875 RGD
part of protein-DNA complex IDA
IDA: Inferred from direct assay
19765194 RGD
part of protein-DNA complex IPI
IPI: Inferred from physical interaction
10362258 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp1

trans-acting transcription factor 1

Sp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sp1 Q01714 Nfya Rattus norvegicus P18576 10393239
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp1 NCBI NCBI:6667
Macaca fascicularis Sp1 NCBI NCBI:102115996
Mus musculus Sp1 NCBI NCBI:20683
Macaca mulatta Sp1 NCBI NCBI:702710